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	Provedor de dados BJPS (3) BABT (1) Autor Silva-Cunha,Armando (4) Fialho,Sílvia Ligório (3) Andrade,Gracielle Ferreira (1) Bastos,Leandro Francisco Silva (1) Caux,Thaís Rolla (1) Coelho,Márcio Matos (1) Costa,Bruna Lopes (1) Godin,Adriana Martins (1) Guedes,Roberto Maurício Carvalho (1) Lobato,Zélia Inês Portela (1) Macedo,Ludmila Branco (1) Machado,Renes Resende (1) Melo,Cristiane da Silva (1) Menezes,Raquel Rezende (1) Moraes,Márcio Flávio Dutra (1) Pena,Roberta Ribas (1) Pereira,Bruno Gonçalves (1) Pereira,Vinícius Viana (1) Sousa,Lirlândia Pires (1) Toledo,Cibele Rodrigues (1) Mais... Palavra-chave Absorbable Implants/ trends (1) Antiangiogenic activity (1) Biocompatibility (1) Chronic Constriction Injury (1) Corosolic acid (1) Delivery device (1) Dexamethasone/ pharmacology (1) Emulsion (1) Hepatitis C/treatment (1) Immunology (1) Implant (1) Interferon alfa (1) Microemulsion (1) NF-kappa B/ drug effects (1) Neuralgia/ chemically induced (1) Neuropathic Pain/ chemically induced (1) Nuclear Factor kappa B/ drug effects (1) PLGA (1) Poly- ε-caprolactone/development (1) Poly- ε-caprolactone/microspheres (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2020 (1) 2019 (1) 2013 (1) 2012 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Evaluation of different adjuvants formulations for bluetongue vaccine BABT Macedo,Ludmila Branco; Lobato,Zélia Inês Portela; Fialho,Sílvia Ligório; Viott,Aline de Marco; Guedes,Roberto Maurício Carvalho; Silva-Cunha,Armando. This study investigated the adjuvant potential of W/O/W multiple emulsions and microemulsions, comparing them with traditional aluminum hydroxide and oil-in-water emulsion adjuvants against bluetongue vaccine (BTV). Local inflammatory reactions were assessed in rabbits by measuring the temperature of the animals and the skin thickness at the site of application. Antibodies titers were determined by serum-neutralization test. Histological analyses of lesions at the site of adjuvants application were done. Results showed that multiple emulsion and microemulsion maintained their stability even in the presence of complex components and presented adequate characteristics for subcutaneous administration. They were able to induce immune response against BTV, but... Tipo: Info:eu-repo/semantics/article Palavras-chave: Emulsion; Microemulsion; Vaccine adjuvants; Immunology; Biocompatibility. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000600007 Delay of neuropathic pain sensitization after application of dexamethasone-loaded implant in sciatic nerve-injured rats BJPS Bastos,Leandro Francisco Silva; Vago,Juliana Priscila; Caux,Thaís Rolla; Costa,Bruna Lopes; Godin,Adriana Martins; Menezes,Raquel Rezende; Pena,Roberta Ribas; Silva-Cunha,Armando; Sousa,Lirlândia Pires; Machado,Renes Resende; Moraes,Márcio Flávio Dutra; Fialho,Sílvia Ligório; Coelho,Márcio Matos. Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammatory effects induced by a dexamethasone-loaded biodegradable implant. Chronic constriction injury (CCI) of the sciatic nerve was performed in Wistar rats. The electronic von Frey test was applied to assess mechanical allodynia. The dexamethasone-loaded implant was placed perineurally at the moment of CCI or 12 days after surgery. Dorsal root ganglia (DRG; L4-L5) were harvested and nuclear extracts were assayed by Western blot for detection of nuclear factor (NF)-κB p65/RelA translocation. Dexamethasone delivered... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic Constriction Injury; Dexamethasone/ pharmacology; Delivery device; Neuropathic Pain/ chemically induced; Nuclear Factor kappa B/ drug effects; Neuralgia/ chemically induced; NF-kappa B/ drug effects; Sciatic Nerve/ injuries; Absorbable Implants/ trends. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100591 Poly-ε-caprolactone microspheres containing interferon alpha as alternative formulations for the treatment of chronic hepatitis C BJPS Melo,Cristiane da Silva; Pereira,Bruno Gonçalves; Silva-Cunha,Armando; Fialho,Sílvia Ligório. Interferon-alpha (IFN-alpha) is one of the main drugs used in the treatment of hepatitis C. Use of IFN-alpha has some limitations that result in poor treatment efficacy and low patient compliance. Therefore, the aim of this study was to develop poly-ε-caprolactone (PCL) microspheres containing IFN-alpha as an alternative for the treatment of chronic hepatitis C. Microspheres were prepared using the multiple emulsion followed by solvent evaporation technique. Particle size, surface morphology, drug content and encapsulation efficiency of the microspheres produced were evaluated. The stability of the formulation was assessed after 90 days at -20ºC. An in vitro release study was performed in PBS. In vitro cytotoxicity of the formulation was studied using... Tipo: Info:eu-repo/semantics/article Palavras-chave: Interferon alfa; Hepatitis C/treatment; Poly- ε-caprolactone/microspheres; Poly- ε-caprolactone/development. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100006 PLGA-corosolic acid implants for potential application in ocular neovascularization diseases BJPS Toledo,Cibele Rodrigues; Pereira,Vinícius Viana; Andrade,Gracielle Ferreira; Silva-Cunha,Armando. Angiogenesis is the formation of new blood vessels from preexisting vasculature. Uncontrolled angiogenesis is associated with progression of several ocular pathologies, such as diabetic retinopathy and macular degeneration. Thus, the inhibition of this process consists in an interesting therapeutic target. Corosolic acid (CA) is a natural derivative of ursolic acid, found in many medicinal herbs and exhibits numerous biological properties, including the antiangiogenic activity. The present study reports the production of CA-loaded poly d,l-lactidecoglycolide acid (PLGA) devices by melt technique. HPLC-UV method was developed and validated to evaluate the uniformity and the release profile of the developed systems. The devices were also characterized by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Corosolic acid; PLGA; Antiangiogenic activity; Implant. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100569 Registros recuperados: 4 Primeira ... 1 ... Última

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