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	Provedor de dados BJMBR (2) Autor Silveira,R. (2) Cardenas,F.P. (1) Cerveñansky,C. (1) Duran,R. (1) Freitas,J.C. (1) Lagos,P. (1) Lamprea,M.R. (1) Morato,S. (1) Walsh,T.J. (1) Mais... Palavra-chave Bunodosoma cangicum (1) Cholinergic immunotoxin (1) Crab nerve (1) Exploratory behavior (1) Hemolytic activity (1) Medial septum (1) Neurotoxins (1) Open-field (1) Saporin (1) Sea anemone (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2003 (1) 2001 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Identification of hemolytic and neuroactive fractions in the venom of the sea anemone Bunodosoma cangicum BJMBR Lagos,P.; Duran,R.; Cerveñansky,C.; Freitas,J.C.; Silveira,R.. Sea anemones are a rich source of biologically active substances. In crayfish muscle fibers, Bunodosoma cangicum whole venom selectively blocks the I K(Ca) currents. In the present study, we report for the first time powerful hemolytic and neuroactive effects present in two different fractions obtained by gel-filtration chromatography from whole venom of B. cangicum. A cytolytic fraction (Bcg-2) with components of molecular mass ranging from 8 to 18 kDa elicited hemolysis of mouse erythrocytes with an EC50 = 14 µg/ml and a maximum dose of 22 µg/ml. The effects of the neuroactive fraction, Bcg-3 (2 to 5 kDa), were studied on isolated crab nerves. This fraction prolonged the compound action potentials by increasing their duration and rise time in a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bunodosoma cangicum; Sea anemone; Hemolytic activity; Neurotoxins; Crab nerve. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000700009 Effects of septal cholinergic lesion on rat exploratory behavior in an open-field BJMBR Lamprea,M.R.; Cardenas,F.P.; Silveira,R.; Walsh,T.J.; Morato,S.. The medial septum participates in the modulation of exploratory behavior triggered by novelty. Also, selective lesions of the cholinergic component of the septohippocampal system alter the habituation of rats to an elevated plus-maze without modifying anxiety indices. We investigated the effects of the intraseptal injection of the cholinergic immunotoxin 192 IgG-saporin (SAP) on the behavior of rats in an open-field. Thirty-nine male Wistar rats (weight: 194-230 g) were divided into three groups, non-injected controls and rats injected with either saline (0.5 µl) or SAP (237.5 ng/0.5 µl). Twelve days after surgery, the animals were placed in a square open-field (120 cm) and allowed to freely explore for 5 min. After the test, the rats were killed by... Tipo: Info:eu-repo/semantics/other Palavras-chave: Exploratory behavior; Open-field; Cholinergic immunotoxin; Medial septum; Saporin. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000200011 Registros recuperados: 2 Primeira ... 1 ... Última

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