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	Provedor de dados Nature Precedings (1) Autor Jianghui Xiong (1) Juan Liu (1) Shanguang Chen (1) Simon Rayner (1) Yinghui Li (1) Ze Tian (1) Mais... Palavra-chave Bioinformatics (1) Biotechnology (1) Cancer (1) Genetics & Genomics (1) Molecular Cell Biology (1) Pharmacology (1) Mais... Tipo do documento Presentation (1) Ano 2010 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última In silico Genetic Network Models for Pre-clinical Drug Prioritization Nature Precedings Jianghui Xiong; Juan Liu; Simon Rayner; Ze Tian; Yinghui Li; Shanguang Chen. The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Patient population heterogeneity and unpredictable physiology complicate pre-clinical cancer modeling efforts. We hypothesize that gene networks associated with cancer outcome in heterogeneous patient populations could serve as a reference for identifying drug effects. Here we propose a novel in vivo genetic interaction which we call ‘synergistic outcome determination’ (SOD), a concept similar to ‘Synthetic Lethality’. SOD is defined as the synergy of a gene pair with respect to cancer patients' outcome, whose correlation with outcome is due to... Tipo: Presentation Palavras-chave: Biotechnology; Cancer; Genetics & Genomics; Molecular Cell Biology; Pharmacology; Bioinformatics. Ano: 2010 URL: http://precedings.nature.com/documents/5343/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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