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| Silva,Viviane Benevenuti; Galdos,Angel Arturo Gaona; Mothe,Cintia Maria Alves; Pallastrelli,Michele Bacchi; Prado,Maria Segunda Aurora; Singh,Anil Kumar; Kedor-Hackmann,Erika Rosa Maria; Santoro,Maria Inês Rocha Miritello. |
| A simple, rapid, economical and reliable high performance liquid chromatographic method has been developed and successfully applied in simultaneous determination of ethinyl estradiol and drospirenone in coated tablets. The HPLC method was performed on a LiChroCART® 100RP column (125x4 mm i.d., 5 µm) with acetonitrile:water 50:50 (v/v) as mobile phase, pumped at a flow rate of 1.0 mL.min-1. The fluorescence detection for ethinyl estradiol was made at λex= 280 nm and λem= 310 nm and a UV detection for drospirenone was made at 200 nm. The elution time for ethinyl estradiol and drospirenone were 4.0 and 5.7 min, respectively. The method was validated in accordance to USP 34 guidelines. The proposed HPLC method presented advantages over reported methods and is... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coated tablets/quantitative analysis; High performance liquid chromatography/quantitative analysis; Ethinyl estradiol/quantitative determination; Drospirenone/quantitative determination; Fluorescence detection; UV detection. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300013 |
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