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Designing L-Systems for making three and six open reading frames from the leading strand of a single DNA molecule Nature Precedings
Arunava Goswami; Rajneesh Singh; Pabitra Choudhury; Sk. Sarif Hassan Hassan.
Current molecular biology dogma (except alternative splicing) suggests that leading strand of DNA produces mRNA and usually the leading strand gives one ORF (ORF) among the available six ORFs. We attempted to break this rule where three and six ORFs from the leading strand will be formed by designing L-Systems, originally proposed to study symmetry of biological world. We thought this would revolutionize the world of synthetic biology. While doing so, we found L-System containing A→T, T→G, C→A, and G→C, i.e., single nucleotide production rule will stop growing after one nucleotide. L-System containing either (a) A→TG, T→GC, C→GA, G→TC or (b) A→CTG,...
Tipo: Manuscript Palavras-chave: Biotechnology; Genetics & Genomics; Molecular Cell Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4844/version/1
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