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| Herman,J.P.; McKlveen,J.M.; Solomon,M.B.; Carvalho-Netto,E.; Myers,B.. |
| The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and to restore homeostasis after the immediate challenge has subsided. Release of glucocorticoids is mediated by the hypothalamo-pituitary-adrenal (HPA) axis, driven by a neural signal originating in the paraventricular nucleus (PVN). Stress levels of glucocorticoids bind to glucocorticoid receptors in multiple body compartments, including the brain, and consequently have wide-reaching actions. For this reason, glucocorticoids serve a vital function in negative feedback inhibition of their... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypothalamo-pituitary-adrenocortical axis; Corticotropin-releasing hormone; Glucocorticoid receptor; Amygdala; Hippocampus; Prefrontal cortex. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400002 |
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