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	Provedor de dados 60 (2) Autor Somasekhar,Vanita (2) Ashok,Purnima (1) Kameswari,Sri Adibatla Renuka (1) Rajendran,Ramaswamy (1) Singh,Rajpreet (1) Palavra-chave 6-Mercaptopurine/determination (1) Ginger (1) High perfomance liquid chromatography/reverse phase/quantitative analysis (1) Pharmaceutical formulations/quality control (1) Phyllanthus emblica Linn (1) Piperine. (1) Vitamin C/antioxidant activity/in vitro study (1) Vitamin C/bioavailability (1) Vitamin C/synthetic/antioxidant activity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2014 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Comparative antioxidant and bioavailability studies of Vitamin C in Phyllanthus emblica Linn. and its combinations with Piper nigrum Linn. and Zingiber officinale Roscoe 60 Somasekhar,Vanita; Ashok,Purnima; Kameswari,Sri Adibatla Renuka; Rajendran,Ramaswamy; Singh,Rajpreet. ABSTRACT Phyllanthus emblica Linn. (amla) is used in Ayurveda, the ancient Indian system of medicine and its major constituent is vitamin C which has effective free radical scavenging property. The purpose of this study was to evaluate the in vitro antioxidant activity and the bioavailability profile of vitamin C in amla and its combinations with piperine and ginger in comparison to synthetic vitamin C using New Zealand rabbits. In vitro antioxidant activity studies of synthetic vitamin C, amla, amla with piperine and amla with ginger were carried out using different models such as 2,2-Diphenyl-1-picrylhydrazyl, Nitric Oxide, Hydrogen peroxide scavenging methods, Total reductive capability and Oxygen Radical Absorbance Capacity estimation. The study... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phyllanthus emblica Linn; Vitamin C/antioxidant activity/in vitro study; Vitamin C/bioavailability; Vitamin C/synthetic/antioxidant activity; Ginger; Piperine.. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100005 Optimization and validation of an RP-HPLC method for the estimation of 6-mercaptopurine in bulk and pharmaceutical formulations 60 Somasekhar,Vanita. A reverse phase HPLC method is described for the determination of 6-mercaptopurine in bulk and tablets. Chromatography was carried on a C18 column using a mixture of acetonitrile and 0.05 mol/L sodium acetate buffer (10:90 v/v) as the mobile phase at a flow rate of 1 mL/min-1 with detection at 324 nm. The retention time of the drug was 3.25 min. The detector response was linear in the concentration of 0.01-5 μg/mL. The limit of detection and limit of quantification were 17 and 52 ng/mL respectively. The method was validated by determining its sensitivity, linearity, accuracy and precision. The proposed method is simple, economical, fast, accurate and precise and hence can be applied for routine quality control of mercaptopurine in bulk and tablets. Tipo: Info:eu-repo/semantics/article Palavras-chave: 6-Mercaptopurine/determination; High perfomance liquid chromatography/reverse phase/quantitative analysis; Pharmaceutical formulations/quality control. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400793 Registros recuperados: 2 Primeira ... 1 ... Última

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