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| Wu,Tao; Zhang,Qianrui; Song,Hongping. |
| The aim of the present study is to illustrate the effects of swertiamarin (STM), a natural iridoid from herbal medicines, on hepatic inflammation induced by carbon tetrachloride (CCl4) in rats. Male Sprague Dawley rats were exposed to CCl4 with or without STM co-administration for 8 weeks. Our results revealed that STM administration (100 and 200 mg/kg b.w.) significantly attenuated inflammation in livers of CCl4-treated rats. STM remarkably reduced the production of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), macrophage inflammatory protein-1a (MIP-1α), and monocyte chemotactic protein-1 (MCP-1) in liver tissue of CCl4-treated rats. In addition, STM treatment downregulated connective tissue growth factor (CTGF) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Swertiamarin/effects; Carbon tetrachloride; Inflammation; TLR4; NF-κB. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400618 |
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| Wu,Tao; Wu,Ji; Gao,Ping; Xiang,Daochun; Liu,Dong; Song,Hongping. |
| abstract The aim of this study was to evaluate the effects of caffeine, tea polyphenol and daidzein on the pharmacokinetics of lansoprazole and its metabolites. Rats were intragastrically administered caffeine (30 mg·kg-1, once per day), tea polyphenol (400 mg·kg-1, once per day) or daidzein (13.5 mg·kg-1, once per day) for 14 days, followed by an intragastric administration of lansoprazole (8 mg·kg-1) on the 15th day. The plasma concentrations of lansoprazole and its two primary metabolites, 5-hydroxylansoprazole and lansoprazole sulfone, were determined by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). Tea polyphenol significantly elevated the Area Under the Curve (AUC) of lansoprazole from 680.29 ± 285.99 to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lansoprazole/pharmacokinetics; Caffeine/effects/lansoprazole pharmacokinetics; Tea polyphenol/effects/lansoprazole pharmacokinetics; Daidzein/effects/lansoprazole pharmacokinetics; 5-hydroxylansoprazole; Lansoprazole sulfone; Hepatic microsomal enzyme/inhibition.. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400893 |
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