|
|
| Grecco,Simone S; Costa-Silva,Thais A; Sousa,Fernanda S; Cargnelutti,Stefano B; Umehara,Eric; Mendonça,Poliana S; Tempone,Andre G; Lago,Joao Henrique G. |
| Abstract Background: The therapeutic arsenal for the treatment of Leishmaniasis is limited and includes toxic compounds (antimonials, amphotericin B, pentamidine and miltefosine). Given these aspects, the search for new compounds based on floristic biodiversity is crucial. In the present work, we report the isolation, characterization and antileishmanial activity of six related neolignans (1–6) of bioactive extract from Nectandra leucantha (Lauraceae) twigs. Methods: Dried and powdered twigs of N. leucantha were exhaustively extracted using n-hexane. The crude extract was dereplicated by HPLC/HRESIMS and subjected to column chromatography to yield pure compounds 1–6. Their chemical structures were identified via NMR and comparison of obtained data with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nectandra leucantha; Leishmania (L.)infantum; Antileishmanial activity; Neolignans. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100318 |
| |
