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| Cavalcanti,Noely Camila Tavares; Sousa,Giovana Damasceno; Tabosa,Maria Alice Maciel; Soares Sobrinho,José Lamartine; Leal,Leila Bastos; Santana,Davi Pereira de. |
| The aim of this study was to characterize three batches of albendazole by pharmacopeial and complementary analytical techniques in order to establish more detailed specifications for the development of pharmaceutical forms. The ABZ01, ABZ02, and ABZ03 batches had melting points of 208 ºC, 208 ºC, and 209 ºC, respectively. X-ray diffraction revealed that all three batches showed crystalline behavior and the absence of polymorphism. Scanning electron microscopy showed that all the samples were crystals of different sizes with a strong tendency to aggregate. The samples were insoluble in water (5.07, 4.27, and 4.52 mg mL-1, respectively) and very slightly soluble in 0.1 M HCl (55.10, 56.90, and 61.70 mg mL-1, respectively) and additionally showed purities... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Albendazole/characterization; Antiparasitics/quality control. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200012 |
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| Leal,Leila Bastos; Sousa,Giovana Damasceno; Seixas,Karoline Belém; Souza,Pedro Henrique Nogueira de; Santana,Davi Pereira de. |
| The aims of this study were to determine the critical hydrophile-lipophile balance (HLB) of licuri oil, and to perform a clinical assay to evaluate its hydrating effects. For the determination of the HLB, serial emulsions were prepared with the oil. Regarding the clinical study, 13 human subjects were recruited to evaluate the hydrating power of the emulsified preparation containing licuri oil, and comparing it with the same preparation containing sweet almond oil (SAO). The critical HLB of licuri oil was represented by the zones within the concentrations of 10% for the oil and 15% for the pair of tensoactive agents, with a value of 11.8. Both preparations showed similar hydrating power. We propose that licuri oil can be considered a new lipophilic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Licuri/fixed oil; Licuri/determination of hydrophile-lipophile balance; Licuri/fixed oil; Licuri/hydration effects; Emulsions/preparation with licuri oil; Skin hydration. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100018 |
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