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| Fregoneze,J.B.; Luz,C.P.; Castro,L.; Oliveira,P.; Lima,A.K.S.; Souza,F.; Maldonado,I.; Macêdo,D.F.; Ferreira,M.G.; Bandeira,I.P.V.; Rocha Jr.,M.A.; Carvalho,F.L.Q.; De-Castro-e-Silva,E.. |
| We have demonstrated that central administration of zinc in minute amounts induces a significant antidipsogenic action in dehydrated rats as well as in rats under central cholinergic and angiotensinergic stimulation. Here we show that acute third ventricle injections of zinc also block water intake induced by central ß-adrenergic stimulation in Wistar rats (190-250 g). Central inhibition of opioid pathways by naloxone reverses the zinc-induced antidipsogenic effect in dehydrated rats. After 120 min, rats receiving third ventricle injections of isoproterenol (160 nmol/rat) exhibited a significant increase in water intake (5.78 ± 0.54 ml/100 g body weight) compared to saline-treated controls (0.15 ± 0.07 ml/100 g body weight). Pretreatment with zinc (3.0,... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Zinc; Isoproterenol; Opioids; Thirst; Naloxone; Rats. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001000007 |
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