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	Provedor de dados BJMBR (2) Autor Harms,J.S. (2) Oliveira,S.C. (2) Splitter,G.A. (2) Bocca,A.L. (1) Goes,A.M. (1) Rech,E.L. (1) Rodarte,R.S. (1) Mais... Palavra-chave Brucella abortus (1) Cytokines (1) DNA vaccine (1) Gene therapy (1) Genetic immunization (1) Intracellular pathogens (1) Knockout mice (1) Regulation (1) T cell subsets (1) Transcription (1) Transgene (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 1999 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Regulation of transgene expression in genetic immunization BJMBR Harms,J.S.; Oliveira,S.C.; Splitter,G.A.. The use of mammalian gene expression vectors has become increasingly important for genetic immunization and gene therapy as well as basic research. Essential for the success of these vectors in genetic immunization is the proper choice of a promoter linked to the antigen of interest. Many genetic immunization vectors use promoter elements from pathogenic viruses including SV40 and CMV. Lymphokines produced by the immune response to proteins expressed by these vectors could inhibit further transcription initiation by viral promoters. Our objective was to determine the effect of IFN-<FONT FACE="Symbol">g</FONT> on transgene expression driven by viral SV40 or CMV promoter/enhancer and the mammalian promoter/enhancer for the major... Tipo: Info:eu-repo/semantics/article Palavras-chave: DNA vaccine; Gene therapy; Regulation; Transcription; Transgene. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200003 The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection BJMBR Oliveira,S.C.; Harms,J.S.; Rech,E.L.; Rodarte,R.S.; Bocca,A.L.; Goes,A.M.; Splitter,G.A.. Cellular immune responses are a critical part of the host's defense against intracellular bacterial infections. Immunity to Brucella abortus crucially depends on antigen-specific T cell-mediated activation of macrophages, which are the major effectors of cell-mediated killing of this organism. T lymphocytes that proliferate in response to B. abortus were characterized for phenotype and cytokine activity. Human, murine, and bovine T lymphocytes exhibited a type 1 cytokine profile, suggesting an analogous immune response in these different hosts. In vivo protection afforded by a particular cell type is dependent on the antigen presented and the mechanism of antigen presentation. Studies using MHC class I and class II knockout mice infected with B. abortus... Tipo: Info:eu-repo/semantics/article Palavras-chave: T cell subsets; Brucella abortus; Knockout mice; Cytokines; Intracellular pathogens; Genetic immunization. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100010 Registros recuperados: 2 Primeira ... 1 ... Última

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