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| Araldi,Rodrigo Pinheiro; Assaf,Suely Muro Reis; Carvalho,Rodrigo Franco de; Carvalho,Márcio Augusto Caldas Rocha de; Souza,Jacqueline Mazzuchelli de; Magnelli,Roberta Fiusa; Módolo,Diego Grando; Roperto,Franco Peppino; Stocco,Rita de Cassia; Beçak,Willy. |
| Abstract In the last decades, a group of viruses has received great attention due to its relationship with cancer development and its wide distribution throughout the vertebrates: the papillomaviruses. In this article, we aim to review some of the most relevant reports concerning the use of bovines as an experimental model for studies related to papillomaviruses. Moreover, the obtained data contributes to the development of strategies against the clinical consequences of bovine papillomaviruses (BPV) that have led to drastic hazards to the herds. To overcome the problem, the vaccines that we have been developing involve recombinant DNA technology, aiming at prophylactic and therapeutic procedures. It is important to point out that these strategies can be... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bovine papillomavirus (BPV); Bovine papillomatosis; Carcinogenesis; Natural history. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000100002 |
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| Góes,Luiz Gustavo Bentim; Freitas,Antonio Carlos de; Ferraz,Oilita Pereira; Rieger,Tania Tassinari; Santos,José Ferreira dos; Pereira,Alexandre; Beçak,Willy; Lindsey,Charles J.; Stocco,Rita de Cassia. |
| The development of a bovine papillomavirus (BPV) vaccine is an outstanding challenge. BPV protein L1 gene transfection in the Drosophila melanogaster S2 cell expression system failed to produce L1 protein notwithstanding correct L1 gene insertion. Severe genetic inbalance in the host cell line, including cytogenetic alterations, may account for the lack of protein expression. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bovine Papillomavirus; BPV4; S2 expression cells. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000100001 |
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