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Use of Ursodeoxycholic Acid on Post-menopausal Obesity, Hepatic steatosis and Plasma Profile as an Alternative Treatment for Hormone Replacement Therapy BABT
Franzoni,Angelo Christiano; Amorim,Aryane Martins; Silva,João Victor Mariano da; Storti,João Augusto Pires; Oliveira,Monique Cristine de.
ABSTRACT The aim of this study was to evaluate the efficacy of the ursodeoxycholic acid (UDCA) as an alternative treatment for menopause pathologies. For this, female Swiss-CD-1 mice were ovariectomized (OVX); SHAM operated mice served as controls. Ten weeks after operation, each group of mice was treated during four weeks with either UDCA, or 17(-estradiol+progesterone. The blood and tissues (liver and periuterine adipose tissue - PUAT) were harvested. The OVX mice had increase body weight, accompanied by liver lipid accumulation. UDCA and HRT treatments reduced these parameters. PUAT was also increased in OVX group and UDCA and HRT treatments reduced this. Histology confirmed the results in the liver and PUAT. The plasma glucose levels were elevated in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Liver disease; Menopause; Obesity; Ursodeoxycholic acid.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000600898
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