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Neutrotoxic effects of fructose administration in rat brain: implications for fructosemia Anais da ABC (AABC)
Macongonde,Ernesto A.; Costa,Naithan L.F.; Ferreira,Bruna K.; Biella,Mairis S.; Frederico,Marisa J.S.; Oliveira,Marcos R. de; Ávila Júnior,Silvio; Silva,Fátima R.M.B.; Ferreira,Gustavo C.; Streck,Emilio L.; Schuck,Patrícia F..
Fructose accumulates in tissue and body fluids of patients affected by hereditary fructose intolerance (HFI), a disorder caused by the deficiency of aldolase B. We investigated the effect of acute fructose administration on the biochemical profile and on the activities of the Krebs cycle enzymes in the cerebral cortex of young rats. Rats received a subcutaneous injection of NaCl (0.9 %; control group) or fructose solution (5 μmol/g; treated group). Twelve or 24 h after the administration, the animals were euthanized and the cerebral cortices were isolated. Peripheral blood (to obtain the serum) and cerebral spinal fluid (CSF) from the animals were also collected. It was observed that albumin levels were decreased and cholesterol levels were increased in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brain damage; Fructose; Fructosemia; Hereditary fructose intolerance; Krebs cycle; Metabolism.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301451
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