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| Registros recuperados: 14 | |
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| Suaib Luqman; Suchita Srivastava. |
| (-)-α-bisabolol is a sesquiterpene alcohol found as a major component of essential oil of chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla L.; Family Asteraceae). Chamomile, one of the most ancient and widely recognized herbs to mankind, has been used traditionally for centuries as an anti-inflammatory, antispasmodic, carminative, mild astringent and healing medicine. It is also known to be very helpful as an external agent for encouraging the rapid healing of ulcers and burns without infection, as well as persistent skin problems such as eczema and psoriasis. Since clinical trials and human studies are limited, we have investigated the effect of (-)-α-bisabolol on markers of oxidative stress in human... |
| Tipo: Poster |
Palavras-chave: Molecular Cell Biology; Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6903/version/1 |
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| Sudeep Roy; Suaib Luqman; Ashok Sharma. |
| The ERG proteins and enzymes of the ergosterol biosynthetic pathway has been the subject of intensive investigation as a target for several classes of antifungal agents used to treat C. albicans infection. Over the past few decades, a number of drugs and inhibitors with wide spectrum of activity, low toxicity and defined targets have been introduced. Several lines of evidence suggest that allylamines targets squalene epoxidase (ERG1), morpholines affects sterol C8-C7 isomerase (ERG2) and sterol reductase (ERG24), azoles inhibits a cytochrome P450 (ERG11) responsible for the 14 α-demethylation of lanosterol and C-5 sterol desaturase (ERG3) and polyenes binds to ergosterol that leads to the damage of cell plasma membrane, ensuing in leakage of... |
| Tipo: Poster |
Palavras-chave: Microbiology; Molecular Cell Biology; Pharmacology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6709/version/1 |
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| Suchita Srivastava; Suaib Luqman; Feroz Khan. |
| Terpenes comprise the most diverse collection of natural products. Out of more than 30,000 individual terpenoids identified, at least half are synthesized by plants. A relatively small, but quantitatively significant, number of terpenoids are involved in primary plant metabolism. However, the vast majorities are classified as secondary metabolites; compounds not required for plant growth and development but presumed to have an ecological function in communication or defense and are widely used in industrial applications. Terpene hydrocarbon scaffolds are generated by the action of the mechanistically intriguing family of mono-, sesqui-, and diterpene synthases collectively termed as terpene synthases, that catalyze multistep reactions with diphosphorylated... |
| Tipo: Poster |
Palavras-chave: Biotechnology; Molecular Cell Biology; Bioinformatics; Plant Biology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6909/version/1 |
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| Suaib Luqman; Tamara P. Kondratyuk; Juma Hosino; Mark Cushman; John M. Pezzuto. |
| As demonstrated previously, resveratrol (3,4',5-trihydroxy-trans-stilbene) inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC), the key rate limiting enzyme in mammalian polyamine synthesis. Using human bladder epithelial carcinoma HTB-24 cells in culture where resveratrol inhibits induction with an IC50 of 8.8 µM, we now report potential metabolites demonstrate greater activity [tetrabutylammonium (E)-4-(3,5-dihydroxystyryl)phenyl sulfate (IC50 1.2 µM), resveratrol tripotassium 3,5,4'-trisulfate (IC50 1.8 µM), resveratrol tripotassium 3,4'-disulfate (IC50 1.8 µM), and resveratrol tripotassium 3,5-disulfate (IC50 2.3 µM)]. Based on RT-PCR... |
| Tipo: Poster |
Palavras-chave: Cancer; Chemistry; Molecular Cell Biology; Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6908/version/1 |
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| Vijaya Dubey; Nusrat Masood; Suaib Luqman; Arvind S. Negi. |
| Cancer, one of the leading causes of death worldwide, is an abnormal cell proliferation that fails to respond to the normal signals. In an effort to eradicate the growing menace of cancer, a clear understanding of fundamental biology and molecular mechanism of carcinogenesis is essential for targeted therapies. Among the devised strategies in use for cancer treatment, the one that is of immense interest is the development of plant based novel anticancer agents. Due to their tremendous availability, biological activity and efficacy, the phytochemicals deemed a gibbous future in chemoprevention. In the present study, several phenolics based structurally related compounds of steroidal and non-steroidal skeleton were synthesized and tested for their... |
| Tipo: Poster |
Palavras-chave: Cancer; Chemistry; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6644/version/1 |
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| Himanshu Tripathi; Abha Meena; Feroz Khan; Suaib Luqman. |
| There are growing examples of drug resistance in the fungal pathogens to evade antifungal drugs by developing mutation in the key targeted enzymes and high expression of drug transporter genes including ABC transporters and MFS transporters. This led to the urgent need to identify novel (unique or essential to fungus) targets that can be used in development of potential antifungal drugs. We have used a comparative genomics approach to find out novel targets in opportunistic fungus, Candida albicans responsible for severe infection in immunocompromised humans. To identify novel targets we have analyzed available total 14,633 protein sequences (proteome) of C. albicans [SC5314] retrieved through RefSeq, an experimentally curated reference sequence database... |
| Tipo: Poster |
Palavras-chave: Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6619/version/1 |
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| Suaib Luqman; Ritesh Kumar; Shubhangi Kaushik; Suchita Srivastava; Mahendra P. Darokar; Suman P. S. Khanuja. |
| Vetiveria zizanioides, popularly known as ‘KHUS’ grass, has been known to India since ancient times. It is the major source of well-known oil of vetiver, which is used in medicine and in perfumery. A concentration-dependent ferric reducing, free radical scavenging and antioxidant activity of two genotypes, namely KS 1 and gulabi of vetiver (Vetiveria zizanioides L. Nash) root, were evaluated by using in vitro assays: the ferric reducing antioxidant power (FRAP), 1, 1-Diphenyl-2-picrylhydrazyl (DPPH), total phenolic content (TPC), total antioxidant capacity (TAC) and reducing power (RP) assay. A positive co-relation was observed between FRAP, DPPH and TPC of cv KS 1, whereas TAC and RP showed a negative co-relation. A significant... |
| Tipo: Poster |
Palavras-chave: Molecular Cell Biology; Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6920/version/1 |
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| Debabrata Chanda; K Patider; Anirban Pal; Suaib Luqman; D U. Bawankule; D N. Mani; Narayan P. Yadav. |
| Asparagus racemosus Willd., one of the most important medicinal plants, is regarded as a ‘rasayana’ in the Ayurvedic system of medicine and has been recommended for use as a galactagogue, aphrodisiac, anodyne, diuretic and nerve tonic since time immemorial, necessitating its incorporation into a number of important Ayurvedic formulations like Shatavarikalpa, Phalaghrita and Vishnutaila. However, data regarding safety or toxicity of Asparagus racemosus in animal systems is lacking. Hence, the present experiment envisaged acute and sub-acute toxicity of Asparagus racemosus root aqueous extract in adult Charles Foster rats following the guidelines of OECD including parameters like observational, hematological, biochemical and... |
| Tipo: Poster |
Palavras-chave: Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6921/version/1 |
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| Suaib Luqman. |
| Moringa oleifera of family Moringaceae, commonly known as Horseradish-tree or the Ben-oil tree is an exceptionally nutritious vegetable tree with a variety of medicinal uses, distributed in tropical and subtropical regions of the world. The tree's bark, roots, fruit (pod), flowers, leaves, seeds and gum are used as an antiseptic, anticancer, anti-inflammatory, hepatoprotective and in treating rheumatism, venomous bites and other conditions. The immature green pods, called ‘drumsticks’ are probably the most valued and widely used part of the tree for water purification (e.g. desalination of ocean salt water). The leaves are highly nutritious, being a significant source of beta-carotene, vitamin C, protein, iron and potassium... |
| Tipo: Presentation |
Palavras-chave: Molecular Cell Biology; Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6924/version/1 |
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| Suaib Luqman; Abha Meena; Laura E. Marler; Tamara P. Kondratyuk; John M. Pezzuto. |
| Target-specific drugs, including natural products, offer promise for the amelioration of cancer and other human ailments with reduced side-effects. Capsaicin, the pungent ingredient present in chillies (Capsicum annuum L.), and capsazepine, a synthetic analogue of capsaicin (collectively referred to as vanilloids), are known to possess a variety of pharmacological and physiological properties. In our continuous effort to discover cancer chemopreventive agents from natural products, we investigated the effect of vanilloids on NFκB activation with stably transfected 293/NFκB-Luc human embryonic kidney cells induced by treatment with tumor necrosis factor (TNFα), and aromatase activity. Capsaicin and capsazepine blocked... |
| Tipo: Poster |
Palavras-chave: Cancer; Molecular Cell Biology; Pharmacology; Bioinformatics. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6913/version/1 |
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| Registros recuperados: 14 | |
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