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| Feng,H.J.; Ouyang,W.; Liu,J.H.; Sun,Y.G.; Hu,R.; Huang,L.H.; Xian,J.L.; Jing,C.F.; Zhou,M.J.. |
| Hypertrophy is a major predictor of progressive heart disease and has an adverse prognosis. MicroRNAs (miRNAs) that accumulate during the course of cardiac hypertrophy may participate in the process. However, the nature of any interaction between a hypertrophy-specific signaling pathway and aberrant expression of miRNAs remains unclear. In this study, Spague Dawley male rats were treated with transverse aortic constriction (TAC) surgery to mimic pathological hypertrophy. Hearts were isolated from TAC and sham operated rats (n=5 for each group at 5, 10, 15, and 20 days after surgery) for miRNA microarray assay. The miRNAs dysexpressed during hypertrophy were further analyzed using a combination of bioinformatics algorithms in order to predict possible... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cardiac hypertrophy; Signaling pathway; Biomarker. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000500361 |
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