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	Provedor de dados BABT (4) Autor Türkez,Hasan (4) Geyikoglu,Fatime (2) Toğar,Başak (2) Aslan,Ali (1) Demir,Leyla (1) Sozio,Piera (1) Stefano,Antonio Di (1) Çelik,Kübra (1) Mais... Palavra-chave Genotoxicity (4) Aflatoxin B1 (2) Cytotoxicity (2) Selenium (2) Sister-chromatid exchanges (2) Antioxidant activity (1) Blood (1) Diffractaic acid (1) Guaiazulene (1) Human blood (1) Oxidant status (1) Oxidative status (1) Whole blood cultures (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2015 (2) 2006 (1) 2005 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última The investigation of cytogenetic and oxidative effects of diffractaic acid on human lymphocyte cultures BABT Demir,Leyla; Toğar,Başak; Türkez,Hasan; Sozio,Piera; Aslan,Ali; Stefano,Antonio Di. Diffractaic acid (DA) is a naturally occurring depside derivative found in several lichen species. It has a wide range of important biological effects such as analgesic and antiviral properties, although its cytotoxic, cytogenetic and oxidative effects have not been investigated in human blood tissue yet. Therefore, increasing concentrations (1, 5, 10, 25, 50, 100 and 200 mgL-1) of DA was added into human whole blood cultures. 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyl tetrazolium bromide (MTT) assay was used to assess the cell viability and/or cytotoxicity and genotoxic damage potential of DA using chromosome aberration (CA) and micronucleus (MN) tests were performed. In addition, oxidative alterations were determined by the total antioxidant capacity... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diffractaic acid; Cytotoxicity; Human blood; Genotoxicity; Oxidative status. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000100075 In vitro cytotoxic, genotoxic and antioxidant/oxidant effects of guaiazulene on human lymphocytes BABT Toğar,Başak; Çelik,Kübra; Türkez,Hasan. The aim of this study was to evaluate for the cytotoxicity, genotoxicity and antioxidant/oxidant activity of GYZ on human peripheral blood lymphocytes (PBLs). Guaiazulene (GYZ) was added into culture tubes at various concentrations (0-400 µg/mL-1). Cytotoxicity against the human lymphocytes cultures was examined by lactate dehydrogenase (LDH) release assay. The proliferative response was estimated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Antioxidant/oxidant activity was evaluated by measuring the total oxidant status (TOS) and total antioxidant capacity (TAC) levels. Micronucleus (MN) and chromosomal aberration (CA) tests were used in genotoxicity studies. The results showed that GYZ caused cytotoxicity in the PBLs at... Tipo: Info:eu-repo/semantics/article Palavras-chave: Guaiazulene; Cytotoxicity; Genotoxicity; Antioxidant activity; Oxidant status. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000100061 Protective effect of sodium selenite on genotoxicity to human whole blood cultures induced by aflatoxin B1 BABT Geyikoglu,Fatime; Türkez,Hasan. The aim of this study was to investigate the effects of selenium and aflatoxin on human whole blood cultures (WBC) in relation to induction of sister-chromatid exchange (SCE). Results showed that the frequency of SCEs in peripheral lymphocytes was significantly increased by the direct-acting mutagen AFB1 (at doses 5 and 10 µM except for 1µM) compared with controls. When sodium selenite (Na2SeO3) was added at a molar ratio of 5x10-7 and 1x10-6, cells did not show significant increase in SCE frequency. Whereas, SCE rates induced by the various AFB1 concentrations could be significantly reduced by the presence of Na2SeO3 in a clear dose-related manner. These results indicated that selenite and AFB1 mutually antagonized their ability to cause DNA damage... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aflatoxin B1; Selenium; Sister-chromatid exchanges; Genotoxicity; Blood. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000800006 Protective effect of sodium selenite against the genotoxicity of aflatoxin B1 in human whole blood cultures BABT Geyikoglu,Fatime; Türkez,Hasan. This study was designed to investigate the effects of selenium and aflatoxin on human whole blood cultures (WBC) in relation to induction of sister-chromatid exchange (SCE). The results showed that the frequency of SCEs in peripheral lymphocytes was significantly increased by the direct-acting mutagen AFB1 (at doses 5 and 10 µM except for 1µM) compared to controls. When sodium selenite (Na2SeO3) was added alone at a molar ratio of 5x10-7 and 1x10-6, cells did not show significant increase in SCE frequency. Whereas, SCE rates induced by the various AFB1 concentrations could be significantly reduced by the presence of Na2SeO3 in a clear dose-related manner. These results indicated that selenite and AFB1 mutually antagonized their ability to cause DNA damage... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aflatoxin B1; Selenium; Sister-chromatid exchanges; Genotoxicity; Whole blood cultures. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000400006 Registros recuperados: 4 Primeira ... 1 ... Última

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