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| SOARES,DÉBORA B.S.; DUARTE,LUCIENIR P.; CAVALCANTI,ANDRÉ D.; SILVA,FERNANDO C.; BRAGA,ARIADNE D.; LOPES,MIRIAM T.P.; TAKAHASHI,JACQUELINE A.; VIEIRA-FILHO,SIDNEY A.. |
| ABSTRACT The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Psychotria viridis Rubiaceae N; N-dimethyltryptamine B16F10 4T1 tumor cells. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000300927 |
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| BOAVENTURA,MARIA AMÉLIA D.; XAVIER,LAURA F.W.; VIEIRA,HENRIETE S.; TAKAHASHI,JACQUELINE A.; NASCIMENTO JUNIOR,WILTON J.D.; ARAUJO,TAMIRES P.; COELHO,AMANDA C.S.. |
| ABSTRACT Thirteen natural products derivatives of hydroxyl amide class, three described for the first time, were synthesized by reaction of three indole acids and 3,4,5-trimethoxybenzoic acid with six different amino alcohols in the presence of triphenylphosphine and N-bromosuccinimide. The derivatives were tested against the Gram (+) bacteria Staphylococcus aureus and Bacillus cereus, Gram (-) Pseudomonas aeruginosa and Escherichia coli, besides the yeast Candida albicans. One of the compounds (7) was selectively active against C. albicans (91.3 ± 0.49% inhibition) showing a great potential as a new drug lead, since it was more active than the positive control, miconazole (88.7 ± 2.41% inhibition). Regarding bacterial inhibition, compounds demonstrated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acetylcholinesterase inhibition antimicrobial activity indole acid derivatives 3; 4; 5-trimethoxybenzoic acid derivatives. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000501945 |
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