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| YAMADA, Kazutaka; TANABE, Shinobu; UENO, Hiroshi; OINUMA, Akemi; TAKAHASHI, Toyomi; MIYAUCHI, Satoshi; SHIGENO, Satoshi; HIROSE, Tsuneo; MIYAHARA, Kazuro; SATO, Motoyoshi; 山田, 一孝; 宮原, 和郎. |
| Chondroitinase ABC (C-ABC) is expected to be a novel agent for chemonucleolysis. The effect of C-ABC was investigated by magnetic resonance (MR) and radiograph. C-ABC was administered into the lumbar intervertebral disks on the clinically normal beagles (n=5), in a dose of 50 μl (12.5 units as C-ABC). MR scans were performed pre-dose, and 1, 3, 7, 14 and 28 days after administration of C-ABC, and the signal intensity (SI) of the nucleus pulposus was measured. Radiographs were taken pre-dose, and 1, 2, 3, 4, 5, 6, 7, 14 and 28 days post-dose, to evaluate narrowing of the disk space in terms of height index (HI). In addition, the quantity of the chondroitin sulfate (CS) and the hyaluronic acid (HA) in the nucleus pulposus were measured by high performance... |
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Palavras-chave: Canine; Chemonucleolysis; Chondroitinase ABC (C-ABC); Height index (HI); Magnetic resonance (MR). |
| Ano: 2001 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4181 |
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