|
|
| Alami,Faranak Mahmoudi; Ahmadi,Mehran; Bazrafshan,Hamidreza; Tabarraei,Alijan; Khosravi,Ayyoob; Tabatabaiefar,Mohammad Amin; Samaei,Nader Mansour. |
| In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108-1.918, p = 0.007). A significant difference in TT genotype was observed between... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: TCF7L2 gene; Rs12255372 variant; Type 2 diabetes mellitus (T2DM); Single nucleotide polymorphism (SNP). |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300005 |
| |
