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| Rosa,Damiana Diniz; Reis,Sandra Aparecida dos; Siqueira,Nathane Pais; Gonçalves,Reggiani Vilela; Machado,Alessandra Barbosa Ferreira; Tafuri,Natália Filardis; Leite,João Paulo Viana; Matta,Sérgio Luís Pinto da; Peluzio,Maria do Carmo Gouveia. |
| ABSTRACTThe aim of this study was to investigate the effect of the bark extractBathysa cuspidata on chemically induced preneoplastic colorectal lesions in Wistar rats. Forty male rats were randomly divided into four groups (n = 10 each): saline (control group, oral administration of saline solution 0.9%); dimethylsulfoxide (DMSO, vehicle control), B200 (treated with 200 mg/kg bark extract ofB. cuspidata), and B400 (treated with 400 mg/kg bark extract ofB. cuspidata). Administration of treatments was carried out by the gavage. The animals received four subcutaneous injections of 1,2-dimethylhydrazine (DMH, 40 mg/kg) in the initial two weeks of the experiment to induce preneoplastic colorectal lesions. After 15 weeks, the animals were euthanized and the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bathysa cuspidata; Animal model; Oxidative stress; Aberrant crypt foci. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000500732 |
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