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	Provedor de dados BABT (1) BJPS (1) Autor Ferraz,Humberto Gomes (2) Takahashi,Andrea Ikeda (2) Andréo Filho,Newton (1) Consiglieri,Vladi Olga (1) Duque,Marcelo Dutra (1) Issa,Michele Georges (1) Lourenço,Felipe Rebello (1) Pessole,Letícia (1) Mais... Palavra-chave Binders/evaluation (1) Dissolution efficiency (1) Drug delivery/evaluation (1) Extrusion/spheronization process (1) Fluid bed (1) Granulation (1) Nimodipine (1) Pellets/dissolution profile (1) Pellets/physicochemical characteristics (1) Spironolactone (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Using fluid bed granulation to improve the dissolution of poorly water-soluble drugs BABT Takahashi,Andrea Ikeda; Lourenço,Felipe Rebello; Duque,Marcelo Dutra; Consiglieri,Vladi Olga; Ferraz,Humberto Gomes. In this study, fluid bed granulation was applied to improve the dissolution of nimodipine and spironolactone, two very poorly water-soluble drugs. Granules were obtained with different amounts of sodium dodecyl sulfate and croscarmellose sodium and then compressed into tablets. The dissolution behavior of the tablets was studied by comparing their dissolution profiles and dissolution efficiency with those obtained from physical mixtures of the drug and excipients subjected to similar conditions. Statistical analysis of the results demonstrated that the fluid bed granulation process improves the dissolution efficiency of both nimodipine and spironolactone tablets. The addition of either the surfactant or the disintegrant employed in the study proved to have... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fluid bed; Granulation; Dissolution efficiency; Nimodipine; Spironolactone. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300020 Physicochemical and dissolution profile characterization of pellets containing different binders obtained by the extrusion-spheronization process BJPS Issa,Michele Georges; Pessole,Letícia; Takahashi,Andrea Ikeda; Andréo Filho,Newton; Ferraz,Humberto Gomes. With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylmethylcellulose and methylcellulose, and we evaluated their different binding properties. The pellets were obtained by the extrusion/spheronization process and were subsequently subjected to fluid bed drying. In order to assess drug delivery, the United States Pharmacopeia (USP) apparatus 3 (Bio-Dis) was employed, in conjunction with the method described by the same pharmacopeia for the dissolution of paracetamol tablets (apparatus 1). The pellets were also evaluated for granulometry, friability, true density and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Binders/evaluation; Pellets/dissolution profile; Pellets/physicochemical characteristics; Extrusion/spheronization process; Drug delivery/evaluation. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300004 Registros recuperados: 2 Primeira ... 1 ... Última

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