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| Lima,Matheus Thomaz Nogueira Silva; Santos,Larissa Batista dos; Bastos,Rafael Wesley; Nicoli,Jacques Robert; Takahashi,Jacqueline Aparecida. |
| ABSTRACT Major health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitory activities, using epigenetic modulation to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase inhibitor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Acetylcholinesterase inhibition; Epigenetic modulation; Penicillium sp.; Talaromyces sp.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000100169 |
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| Lima,Denise Simim; Duarte,Nathália Barroso Almeida; Barreto,Débora Luiza Costa; Oliveira,Geane Pereira de; Takahashi,Jacqueline Aparecida; Fabrini,Sabrina Pinheiro; Sande,Denise. |
| ABSTRACT: The waste in the fruit production chain, including the juice and pulp industries, produces large quantities of leftover husks, seeds and bagasse. This volume of waste generates huge environmental and economic impact. The objective of this research was to determine the potential of using residues from passion fruit (Passiflora edulis) and apple (Malus domestica) varieties in the production of functional flours. Passion fruit flour showed greater reduction of DPPH (EC50%: 50.4μg/mL) radicals, showing antioxidant potential, as well as a more efficient inhibition of Staphylococcus aureus (71.3±1.2μg/mL), with a modest; however efficient, inhibition of acetylcholinesterase (10%). All Apple flours were good antioxidants and the fuji apple flour stood... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acetylcholinesterase; Agroindustrial residues; Antioxidant; Natural preservative. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000900754 |
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