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Formulation and evaluation of CFC free inhalers for beclomethasone dipropionate 60
Talasila,Gopala Krishna Murthy; Mukkala,Bala Vishnu Priya; Vattikuri,Satyanarayana.
Beclomethasone dipropionate CFC free inhalation formulations were developed with a view to treat asthma prophylactically. Dry powder inhalers (DPI) for beclomethasone dipropionate were prepared with different grades of lactose monohydrate. The influence of carrier and overages on performance of DPI was studied. Metered dose inhalers (MDI) with HFA based propellants were formulated with various doses, overages and different concentrations of alcohol. Formulated DPI and MDI were evaluated for various official and unofficial quality control tests. The influence of over doses on valve delivery, effect of overages on emitted dose and influence of alcohol on spray pattern from MDI were studied. The better fine particle fraction and emitted dose were obtained...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Beclomethasone dipropionate Dry powder inhalers Metered dose inhalers; ; Emmited dose Fine particle fraction; Overages.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200004
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