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| Qiu,Qing-chao; Hu,Bo; He,Xiu-pei; Luo,Qiao; Tang,Guo-hua; Long,Zhi-feng; Chen,Zhu-chu; He,Xiu-sheng. |
| STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in nude mice injected subcutaneously with Tet/pTRE-STGC3/CNE2 cells. STGC3 expression was induced by the intraperitoneal injection of doxycycline (Dox). The volume mean of Tet/pTRE-STGC3/CNE2+Dox xenografts was smaller than that of Tet/pTRE/CNE2+Dox xenografts. In addition, Tet/pTRE-STGC3/CNE2+Dox xenografts showed an increase in the percentage of apoptotic cells, a decrease in Bcl-2 protein expression and an increase in Bax protein expression. A proteomic approach... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: CNE2 cell line; Nasopharyngeal carcinoma; Nude mouse; STGC3; Tet-on; Two-dimensional electrophoresis. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000100002 |
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