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| Monteiro,Lis Marie; Tavares,Guilherme Diniz; Ferreira,Elizabeth Igne; Consiglieri,Vladi Olga; Bou-Chacra,Nadia Araci; Löbenberg,Raimar. |
| Hydroxymethylnitrofurazone (NFOH) is a new compound with potential leishmanicidal and trypanocidal activity. Despite its effectiveness, the formulators have to overcome its poor aqueous solubility. Recently, polymeric nano-scale drug delivery systems have proposed for the treatment of neglected diseases. As several studies have confirmed the advantages of such formulations, and this approach provides new analytical challenges, including the need to detect trace amounts of the drug. A suitable method was developed and validated for NFOH determination bound to poly (n-butylcyanoacrylate) (PBCA) nanoparticles. The chromatographic separation was achieved using a C18 column maintained at 25 ºC and an isocratic mobile phase consisting of water and acetonitrile:... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hydroxymethylnitrofurazone/determinação; Nanoparticle; High-performance liquid chromatography/reverse phase/quantitative analysis; Poly(n-butylcyanoacrylate)/nanoparticles/encapsulation. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300561 |
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| Barbosa,Bruna Renata Dutra; Barbosa,Sávio Fujita; Tavares,Guilherme Diniz; Chacra,Nádia Araci Bou; Pinto,Terezinha de Jesus Andreoli. |
| Age-related macular degeneration (AMD) is an ocular inflammatory diseases treated mainly by means of a bevacizumab (Avastin®) or ranibizumab (Lucentis®) intravitreal injection. Among these drugs, only ranibizumab has a specific therapeutic indication for AMD. Considering that, the off-label use on ophthalmic therapy seems to become a rule when it should be an exception. Furthermore, bevacizumab presentation consists of multi-dose vials although it does not contain preservatives in its formula. The current literature review aimed at assessing the risks for the patient related to the use of off-label indication and multi-dose vials on AMD treatment. Considering this, the proposal related to the Brazilian Public Consultation no.10, dated September 12, 2012,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Age-related macular degeneration/treatment; Ranibizumab/intravitreal injection; Bevacizumab/intravitreal injection; Ophthalmic therapy/off-label use; Off-label indication/patients risks; Multi-dose vials/patients risks. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100006 |
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