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	Provedor de dados BJMBR (4) Autor Tedesco,A.C. (4) Lunardi,C.N. (2) Borissevitch,I.E. (1) Daghastanli,N.A. (1) Degterev,I.A. (1) Gomes,A.J. (1) Gonzalez,S. (1) Nunes,S.M.T. (1) Rotta,J.C.G. (1) Sguilla,F.S. (1) Mais... Palavra-chave Liposomes (2) Zinc phthalocyanine (2) Antioxidant (1) Bovine serum albumin (1) Cardiolipin (1) Chloroaluminum phthalocyanine (1) Cholesterol (1) Dimyristoyl phosphatidylcholine (1) Kojic acid (1) Nitric oxide (1) Nitrofurane derivatives (1) Oxygen and nitrogen active species (1) Photodynamic therapy (1) Phototoxicity (1) Polypodium leucotomos extract (1) Quinifuryl (1) Reactive oxygen species (1) S-nitrosothiols (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2004 (2) 2003 (1) 2001 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Photocytotoxicity of a 5-nitrofuran-ethenyl-quinoline antiseptic (Quinifuryl) to P388 mouse leukemia cells BJMBR Daghastanli,N.A.; Degterev,I.A.; Tedesco,A.C.; Borissevitch,I.E.. Quinifuryl (MW 449.52), 2-(5'-nitro-2'-furanyl)ethenyl-4-{N-[4'-(N,N-diethylamino)-1'-methylbutyl]carbamoyl} quinoline, is a water soluble representative of a family of 5-nitrofuran-ethenyl-quinoline drugs which has been shown to be highly toxic to various lines of transformed cells in the dark. In the present study, the toxicity of Quinifuryl to P388 mouse leukemia cells was compared in the dark and under illumination with visible light (390-500 nm). Illumination of water solutions of Quinifuryl (at concentrations ranging from 0.09 to 9.0 µg/ml) in the presence of P388 cells resulted in its photodecomposition and was accompanied by elevated cytotoxicity. A significant capacity to kill P388 cells was detected at a drug concentration as low as 0.09 µg/ml.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phototoxicity; Nitrofurane derivatives; Quinifuryl; Oxygen and nitrogen active species. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200013 The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions with reactive oxygen species BJMBR Gomes,A.J.; Lunardi,C.N.; Gonzalez,S.; Tedesco,A.C.. Two natural products Polypodium leucotomos extract (PL) and kojic acid (KA) were tested for their ability to scavenge reactive oxygen species (·OH, ·O2-, H2O2, ¹O2) in phosphate buffer. Hydroxyl radicals were generated by the Fenton reaction, and the rate constants of scavenging were 1.6 x 10(9) M-1 s-1 for KA and 1.0 x 10(9) M-1 s-1 for PL, similar to that of ethanol (1.4 x 10(9) M-1 s-1). With superoxide anions generated by the xanthine/hypoxanthine system, KA and PL (0.2-1.0 mg/ml) inhibited ·O2-dependent reduction of nitroblue tetrazolium by up to 30 and 31%, respectively. In the detection of ¹O2 by rose bengal irradiation, PL at 1.0 mg/ml quenched singlet oxygen by 43% relative to azide and KA by 36%. The present study demonstrates that PL showed an... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polypodium leucotomos extract; Kojic acid; Antioxidant; Reactive oxygen species. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100018 Nitric oxide release from the S-nitrosothiol zinc phthalocyanine complex by flash photolysis BJMBR Rotta,J.C.G.; Lunardi,C.N.; Tedesco,A.C.. The photogeneration of nitric oxide (NO) using laser flash photolysis was investigated for S-nitroso-glutathione (GSNO) and S-nitroso-N-acetylcysteine (NacySNO) at pH 6.4 (PBS/HCl) and 7.4 (PBS). Irradiation of S-nitrosothiol with light (lambda = 355 nm followed by absorption spectroscopy) resulted in the homolytic decomposition of NacySNO and GSNO to generate radicals (GS· and NacyS·) and NO. The release of NO from donor compounds measured with an ISO-Nometer apparatus was larger at pH 7.4 than pH 6.4. NacySNO was also incorporated into dipalmitoyl-phosphatidylcholine liposomes in the presence and absence of zinc phthalocyanine (ZnPC), a well-known photosensitizer useful for photodynamic therapy. Liposomes are usually used as carriers for hydrophobic... Tipo: Info:eu-repo/semantics/article Palavras-chave: S-nitrosothiols; Nitric oxide; Zinc phthalocyanine; Liposomes; Photodynamic therapy. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500005 Photophysical studies of zinc phthalocyanine and chloroaluminum phthalocyanine incorporated into liposomes in the presence of additives BJMBR Nunes,S.M.T.; Sguilla,F.S.; Tedesco,A.C.. The photophysical properties of zinc phthalocyanine (ZnPC) and chloroaluminum phthalocyanine (AlPHCl) incorporated into liposomes of dimyristoyl phosphatidylcholine in the presence and absence of additives such as cholesterol or cardiolipin were studied by time-resolved fluorescence, laser flash photolysis and steady-state techniques. The absorbance of the drugs changed linearly with drug concentration, at least up to 5.0 µM in homogeneous and heterogeneous media, indicating that aggregation did not occur in these media within this concentration range. The incorporation of the drugs into liposomes increases the dimerization constant by one order of magnitude (for ZnPC, 3.6 x 10(4) to 1.0 x 10(5) M-1 and for AlPHCl, 3.7 x 10(4) to 1.5 x 10(5) M-1), but this... Tipo: Info:eu-repo/semantics/article Palavras-chave: Zinc phthalocyanine; Chloroaluminum phthalocyanine; Bovine serum albumin; Liposomes; Cholesterol; Cardiolipin; Dimyristoyl phosphatidylcholine. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000200016 Registros recuperados: 4 Primeira ... 1 ... Última

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