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Farnesol in combination with N-acetylcysteine against Staphylococcus epidermidis planktonic and biofilm cells BJM
Gomes,Fernanda; Leite,Bruna; Teixeira,Pilar; Azeredo,Joana; Oliveira,Rosário.
Staphylococcus epidermidis is the most frequent cause of nosocomial sepsis and catheter-related infections, in which biofilm formation is considered to be the main virulence mechanism. In biofilm environment, microbes exhibit enhanced resistance to antimicrobial agents. This fact boosted the search of possible alternatives to antibiotics. Farnesol and N-acetylcysteine (NAC) are non-antibiotic drugs that have demonstrated antibacterial properties. In this study, the effect of farnesol and NAC isolated or in combination (farnesol+NAC) was evaluated. NAC at 10 × MIC caused a total cell death in planktonic cells. On the other hand, S. epidermidis biofilms exhibited 4 log reduction in viable cell number after a 24h treatment with NAC at the former...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nosocomial infection; Biofilm; Staphylococci; Farnesol; N- acetylcysteine.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100026
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Adhesion of Salmonella Enteritidis to stainless steel surfaces BJM
Oliveira,Kelly; Oliveira,Tereza; Teixeira,Pilar; Azeredo,Joana; Oliveira,Rosário.
Adhesion of microorganisms to food processing surfaces and the problems it causes are a matter of strong concern to the food industry. Contaminated food processing surfaces may act as potential sources of transmission of pathogens in food industry, catering and in the domestic environments. Several studies have shown that adhesion of bacteria to surfaces partly depends upon the nature of the inert surfaces and partly upon the bacterial surface properties. The aim of this study was to compare the adhesion of four different strains of Salmonella Enteritidis to stainless steel 304 (SS 304). The effect of surface hydrophobicity and surface elemental composition on the adhesion process was also analysed. Hydrophobicity was evaluated through contact angle...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adhesion; Salmonella Enteritidis; Hydrophobicity.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000200026
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