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	Provedor de dados 80 (2) Autor Tempone,Andre G. (2) Conserva,Geanne A. Alves (1) Costa-Silva,Thais A. da (1) Galisteo Jr,Andrés J. (1) Lago,João Henrique G. (1) Pinto,Erika G. (1) Mais... Palavra-chave Amiodarone (1) Antileishmanial (1) Immunomodulatory (1) In vitro (1) In vivo (1) Leishmania (1) Leishmania (L.) infantum chagasi (1) Nectandra oppositifolia (1) Secosubamolide (1) Visceral leishmaniasis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae) 80 Costa-Silva,Thais A. da; Conserva,Geanne A. Alves; Galisteo Jr,Andrés J.; Tempone,Andre G.; Lago,João Henrique G.. Abstract Background: Visceral leishmaniasis is a complex neglected tropical disease caused by Leishmania donovani complex. Its current treatment reveals strong limitations, especially high toxicity. In this context, natural products are important sources of new drug alternatives for VL therapy. Therefore, the antileishmanial and immunomodulatory activity of compounds isolated from Nectandra oppositifolia (Lauraceae) was investigated herein. Methods: The n-hexane extract from twigs of N. oppositifolia were subjected to HPLC/HRESIMS and bioactivity-guided fractionation to afford compounds 1 and 2 which were evaluated in vitro against Leishmania (L.) infantum chagasi and NCTC cells. Results: The n-hexane extract displayed activity against L. (L.) infantum... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania (L.) infantum chagasi; Antileishmanial; Nectandra oppositifolia; Secosubamolide; Immunomodulatory. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100317 Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach 80 Pinto,Erika G.; Tempone,Andre G.. Abstract Background: Considering the high toxicity and limited therapies available for treating visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to deliver new therapies to the market. Methods: In this study, we described for the first time the activity of a potent antiarrhythmic, amiodarone (AMD), against L. (L.)infantum and its in vitro and in vivo activity. Results: The evaluation against promastigotes has shown that amiodarone presents leishmanicidal effect against the extracellular form, with an IC50 value of 10 μM. The activity was even greater against amastigotes in comparison with promastigotes with an IC50 value of 0.5 μM. The selectivity index in relation to the intracellular form demonstrated that the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania; Visceral leishmaniasis; Amiodarone; In vitro; In vivo. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100320 Registros recuperados: 2 Primeira ... 1 ... Última

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