Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Nature Precedings (2) Autor Jorge Sousa (2) Lino Ferreira (2) Tiago Outeiro (2) André X. C. N. Valente (1) André Valente (1) Palavra-chave Neuroscience (2) Tipo do documento Manuscript (2) Ano 2010 (2) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A stem-cell ageing hypothesis on the origin of Parkinson's disease Nature Precedings André Valente; Jorge Sousa; Tiago Outeiro; Lino Ferreira. A transcriptome-wide blood expression dataset of Parkinson’s disease (PD) patients and controls was analyzed under the hypothesis-rich mathematical framework. The analysis pointed towards differential expression in blood cells in many of the processes known or predicted to be disrupted in PD. We suggest that circulating blood cells in PD patients can be in a full-blown PD-expression state. We put forward the hypothesis that sporadic PD can originate as a case of hematopoietic stem cell/differentiation process expression program defect and suggest this research direction deserves further investigation. Tipo: Manuscript Palavras-chave: Neuroscience. Ano: 2010 URL: http://precedings.nature.com/documents/4263/version/1 A stem-cell ageing hypothesis on the origin of Parkinson's disease Nature Precedings André X. C. N. Valente; Jorge Sousa; Tiago Outeiro; Lino Ferreira. A transcriptome-wide blood expression dataset of Parkinson’s disease (PD) patients and controls was analyzed under the hypothesis-rich mathematical framework. The analysis pointed towards differential expression in blood cells in many of the processes known or predicted to be disrupted in PD. We suggest that circulating blood cells in PD patients can be in a full-blown PD-expression state. We put forward the hypothesis that sporadic PD can originate as a case of hematopoietic stem cell/differentiation process expression program defect and suggest this research direction deserves further investigation. Tipo: Manuscript Palavras-chave: Neuroscience. Ano: 2010 URL: http://precedings.nature.com/documents/4263/version/2 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco