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	Provedor de dados BJPS (2) Autor Tiwari,Gaurav (2) Tiwari,Ruchi (2) Gupta,Ankita (1) Rai,A. K. (1) Rai,Awanik (1) Srivastava,Birendra (1) Srivastava,Rishabh (1) Mais... Palavra-chave 5-Fluorouracil (1) Acrylic polymers (1) Colorectal cancer/treatment (1) Drugs/delivery/colon targeting (1) Drugs/extended release (1) Eudragit RL100 (1) Eudragit S100 (1) Extended realease/pharmacotechnics (1) Freeze drying/pharmacotechnics (1) HPMC capsules/enteric coating (1) Microsponges/formulation (1) Pharmaceutical formulations/evaluation (1) Promethazine hydrochloride/extended release (1) Spray drying/pharmacotechnics (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2015 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Extended release promethazine HCl using acrylic polymers by freeze-drying and spray-drying techniques: formulation considerations BJPS Tiwari,Ruchi; Srivastava,Birendra; Tiwari,Gaurav; Rai,Awanik. The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and spray-drying techniques. Solid dispersions were characterized by Fourier-transformed infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), Nuclear magnetic resonance (NMR), Scanning electron microscopy (SEM), as well as solubility and in vitro dissolution studies in 0.1 N HCl (pH 1.2), double-distilled water and phosphate buffer (pH 7.4). Adsorption tests from drug solution to solid polymers were also performed. A selected solid dispersion system was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Promethazine hydrochloride/extended release; Drugs/extended release; Eudragit RL100; Eudragit S100; Acrylic polymers; Spray drying/pharmacotechnics; Freeze drying/pharmacotechnics; Extended realease/pharmacotechnics; Pharmaceutical formulations/evaluation. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400029 Enteric coated HPMC capsules plugged with 5-FU loaded microsponges: a potential approach for treatment of colon cancer BJPS Gupta,Ankita; Tiwari,Gaurav; Tiwari,Ruchi; Srivastava,Rishabh; Rai,A. K.. The work was aimed at developing novel enteric coated HPMC capsules (ECHC) plugged with 5 Florouracil (5-FU) loaded Microsponges in combination with calcium pectinate beads. Modified quasi-emulsion solvent diffusion method was used to formulate microsponges based on 32 factorial design and the effects of independent variables (volume of organic solvent and Eudragit RS100 content) on the dependent variables (Particle size, %EE & % CDR) were determined. The optimized microsponges (F4) were characterized by SEM, PXRD, TGA and were plugged along with calcium pectinate beads in HPMC capsules and the HPMC capsules were further coated with enteric polymer Eudragit L 100 (Ed-L100) and/ or Eudrgit S 100 (Ed-S 100) in different proportions. In vitro release... Tipo: Info:eu-repo/semantics/article Palavras-chave: 5-Fluorouracil; HPMC capsules/enteric coating; Microsponges/formulation; Drugs/delivery/colon targeting; Colorectal cancer/treatment. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300591 Registros recuperados: 2 Primeira ... 1 ... Última

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