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| Gómez-Alvis,A.; Rebolledo,A.; Milesi,V.; Raingo,J.; Sanz,N.; Tommasi,J.; Drago,A.; Rinaldi,G.; Grassi,A.. |
| Hemodynamic care during postoperative management of myocardial revascularization should include vasorelaxing drugs to insure adequate graft and coronary flow, and stimulation of stroke volume to maintain vascular perfusion pressure. We tested the cardiac (inotropic and lusitropic) and vascular (relaxant) effects of diltiazem (0.1 nM to 0.1 mM), dobutamine (10 µM to 10 mM) and amrinone (10 µM to 1 mM) on isolated rat atria and thoracic aorta, and also on isolated human saphenous vein (HSV) and human mammary artery (HMA). Dobutamine produced a maximal positive inotropic effect (+dF/dt max = 29 ± 7%) at its ED50 for aortic relaxation (88 ± 7 µM). Conversely, at their ED50 for aortic relaxation diltiazem depressed myocardial contractility and amrinone did not... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amrinone; Dobutamine; Diltiazem; Saphenous vein; Mammary artery. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600015 |
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