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| Marques,Any de Castro Ruiz; Schiavon,Fabiana Percinoto Monteiro; Travassos,Patricia Batista; Eik,Vanessa Fontana; Godoy,Guilherme; Schamber,Christiano Rodrigues; Bazotte,Roberto Barbosa. |
| ABSTRACT We developed a pre-clinical model in which to evaluate the impact of orally administered carbohydrates on postprandial blood glucose levels. For this purpose, we compared the effects of different carbohydrates with well-established glycemic indexes. We orally administered (gavage) increasing amounts (0.2, 0.4, 0.6, 0.8, and 1.0 g/kg) of sucrose and lactose to rats which had been fasted for 6 h or 15 h, respectively. In part of the experiments we administered frutose (gavagem). Three different models were compared for measuring postprandial blood glucose levels: a) evaluation of interstitial glucose concentrations by using a real time continuous glucose monitoring system; b) evaluation of glucose levels in blood obtained from the rat tail; c)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glycemic index/study; Glycemic index/oral administration; Glycemic load; Interstitial glucose; Real time continuous glucose monitoring system; Carbohydrates/posprandial glucose levels/rats.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400761 |
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| Vilela,Vanessa Rodrigues; Antunes,Marina Masetto; Godoi,Vilma Aparecida Ferreira; Travassos,Patricia Batista; Souza,Helenir Medri de; Bazotte,Roberto Barbosa. |
| ABSTRACT We investigated whether oral lactate could prevent seizures and deaths in mice with severe hypoglycemia induced by a high dose of insulin. For this purpose, mice were fasted for 15 h and then given an intraperitoneal injection of regular insulin (5.0 U/kg or 10.0 U/kg). Immediately after insulin injection, the mice received an oral dose of saline (control), glucose (5.5 mmol/kg), or lactate (18.0 mmol/kg). Glucose and lactate levels were measured in the blood and brain before and after the seizures began. Glucose and lactate delayed (p < 0.05) the onset of seizures associated with severe insulin-induced hypoglycemia. Elevated (p < 0.05) brain levels of lactate were associated with an absence of seizures in mice that received glucose or... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lactatemia; Oral glucose; Diazepam; Seizure; Anticonvulsant effect. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200602 |
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