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| BAYIR,YASIN; UN,HARUN; CADIRCI,ELIF; AKPINAR,EROL; DIYARBAKIR,BUSRA; CALIK,ILKNUR; HALICI,ZEKAI. |
| Abstract Our aim is to investigate the potentially preventive effects of Aliskiren in a carrageenan-induced lung pleurisy model and to compare the standard anti-inflammatory agents, indomethacin and dexamethasone. The pleurisy model was induced through the injection of carrageenan (0.2 ml-%2) into the pleural cavity. After the experiment, serum and lung tissues were collected and biochemical, molecular and pathological examinations were performed. In our study, pleural inflammation decreased superoxide dismutase activity and the glutathione level and increased the malondialdehyde level in the lung of rats, while Aliskiren increased the superoxide dismutase activity and glutathione level and decreased the malondialdehyde level. In addition,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aliskiren; Cytokines; Lung injury; Oxidative stress; Pleurisy; Rat. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100801 |
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