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| Jobim,F.C.; Xavier,N.L.; Uchoa,D.M.; Cruz,D.B.; Saciloto,M.; Chemello,N.; Schwartsmann,G.. |
| Our objective was to determine the presence of vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2) and MMP-9 and specific tissue inhibitors of matrix metalloproteinase (TIMP-1 and TIMP-2) in tumor samples obtained from patients with primary breast cancer. We attempted to correlate these findings with the status of the sentinel lymph node (SLN) and clinical-pathological characteristics such as age, tumor size, histological type, histological grade, and vascular invasion. Tumor samples from 88 patients with primary breast cancer were analyzed. The immunoreactivity of VEGF, MMP-2, MMP-9, TIMP-1, and TIMP-2 in tumors was correlated with clinical and pathological features, as well as SLN status. Nonparametric, Mann-Whittney,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Breast cancer; Vascular endothelial growth factor; Matrix metalloproteinase; Metalloproteinase tissue inhibitors; Sentinel lymph node. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001000018 |
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| Caramori,P.R.A.; Eggers,E.E.; Silva-Filho,A.P.F.; Uchoa,D.M.; Jung,F.; Zago,A.C.; Cerski,C.T.S.; Schwartsmann,G.; Zago,A.J.. |
| Transluminal coronary angioplasty is a routine therapeutic intervention in coronary heart disease. Despite the high rate of primary success, restenosis continues to be its major limitation. Porcine models have been considered to be the most adequate experimental models for studying restenosis. One limitation of porcine models is the need for radiological guidance and the expenses involved. The objective of the present study was to adapt an experimental model of angioplasty in the porcine carotid artery that does not require radiological equipment. Eight animals were used to develop the technique of balloon injury to the common carotid artery by dissection without radiological guidance. This technique was then employed in six other animals. Under... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arterial injury; Intimal hyperplasia; Restenosis; Percutaneous transluminal coronary angioplasty. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900007 |
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