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| Takahashi,Hiroshi; Ikeda,Kazuhiko; Ogawa,Kazuei; Saito,Syunnichi; Ngoma,Alain M; Mashimo,Yumiko; Ueda,Koki; Furukawa,Miki; Shichishima-Nakamura,Akiko; Ohkawara,Hiroshi; Nollet,Kenneth E; Ohto,Hitoshi; Takeishi,Yasuchika. |
| BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS: We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher... |
| Tipo: Journal article |
Palavras-chave: Regulatory T cells; Allogeneic hematopoietic stem cell transplantation; Thymus; Graft-versus-host disease. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041 |
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