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The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest ArchiMer
Mimouni, Virginie; Ulmann, Lionel; Pasquet, Virginie; Mathieu, Marie; Picot, Laurent; Bougaran, Gael; Cadoret, Jean-paul; Morant-manceau, Annick; Schoefs, Benoit.
Through the photosynthetic activity, microalgae process more than 25% of annual inorganic carbon dissolved in oceans into carbohydrates that ultimately, serve to feed the other levels of the trophic networks. Besides, microalgae synthesize bioactive molecules such as pigments and lipids that exhibit health properties. In addition, abiotic stresses, such as high irradiance, nutrient starvation, UV irradiation, trigger metabolic reorientations ending with the production of other bioactive compounds such as omega-3 fatty acids or carotenoids. Traditionally, these compounds are acquired through the dietary alimentation. The increasing, and often unsatisfied, demand for compounds from natural sources, combined with the decrease of the halieutic resources,...
Tipo: Text Palavras-chave: Bioactive compound; Alga; Pigment; Lipid; Health benefit; Abiotic stress; Metabolic reorientation; Diatom.
Ano: 2012 URL: http://archimer.ifremer.fr/doc/00118/22894/20847.pdf
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Nitrogen and phosphorus limitations induce carbon partitioning and membrane lipid remodelling in the marine diatom Phaeodactylum tricornutum ArchiMer
Huang, Bing; Marchand, Justine; Blanckaert, Vincent; Lukomska, Ewa; Ulmann, Lionel; Wielgosz-collin, Gaëtane; Rabesaotra, Vony; Moreau, Brigitte; Bougaran, Gael; Mimouni, Virginie; Morant-manceau, Annick.
Nitrogen (N) and phosphorus (P) limitations induce triacylglycerol (TAG) accumulation and membrane lipid remodelling in the marine diatom Phaeodactylum tricornutum. However, a clear understanding of the metabolic reorientation is still lacking. Carbon partitioning is of great interest because this microalga produces various highly valuable molecules such as lipids and polyunsaturated fatty acids. This study compared growth, photosynthetic activity, biochemical and transcriptional responses of P. tricornutum throughout batch culture under N or P limitation. The integrated results show that the photosynthetic intensity was greatly reduced under N or P limitation. Under N limitation, the degradation and re-use of cellular N-containing compounds contributed to...
Tipo: Text Palavras-chave: Betaine lipid; Lipid remodelling; Microalga; Nitrogen; Phosphorus; Polyunsaturated fatty acid.
Ano: 2019 URL: https://archimer.ifremer.fr/doc/00491/60249/63861.pdf
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