Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BABT (2) Autor Unak,Perihan (2) Acar,Cigdem (1) Demir,Ilknur (1) Muftuler,Fazilet Zumrut Biber (1) Palavra-chave 99mTc (1) Angiogenesis (1) Auger electron radiotherapy (1) Bevacizumab (1) High LET radiation (1) Radionuclide cancer therapy (1) Targeted Tumor Radiotherapy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última In Vivo investigation of radiolabeled Bevacizumab in healthy rat tissues BABT Demir,Ilknur; Muftuler,Fazilet Zumrut Biber; Unak,Perihan; Acar,Cigdem. In this study, BevMab was conjugated with the bifunctional chelating agent [diethylenetriamine pentaacetic acid (DTPA)] and the product (BevMab-DTPA) was labeled with 99mTc using stannous chloride reducing method. The quality control studies of radiolabeled compound (99mTc-BevMab-DTPA) were done with Thin Layer Radio Chromatography (TLRC) and High Performance Liquid Radio Chromatography (HPLRC) methods (% 95 <) to confirm the labeling efficiency. High radiochemical yield [98.07 % ± 2.17 (n = 13)] was obtained by TLRC method. Biodistribution studies of 99mTc labeled BevMab-DTPA was run on healthy female and male Albino Wistar rats. The distribution figures demonstrated that the radiolabeled compound was eliminated through the kidneys and accumulated in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiogenesis; Bevacizumab; 99mTc. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000100010 Targeted tumor radiotherapy BABT Unak,Perihan. Targeted tumor radiotherapy is selectively delivery of curative doses of radiation to malignant sites. The aim of the targeted tumor radiotherapy is to use the radionuclides which have high LET particle emissions conjugated to appropriate carrier molecules. The radionuclides are selectively collected by tumor cells, depositing lethal doses to tumor cells while no admission occur to normal cells. In theory, targeted radiotherapy has several advantages over conventional radiotherapy since it allows a high radiation dose to be administered without causing normal tissue toxicity, although there are some limitations in the availability of appropriate targeting agents and in the calculations of administered doses. Therefore, for routine clinical applications... Tipo: Info:eu-repo/semantics/article Palavras-chave: Targeted Tumor Radiotherapy; Radionuclide cancer therapy; High LET radiation; Auger electron radiotherapy. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500014 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco