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| VELARDE,VICTORIA; DE LA CERDA,PAULA M; DUARTE,CLAUDIA; ARANCIBIA,FRANCISCA; ABBOTT,EDUARDO; GONZÁLEZ,ALEJANDRO; MORENO,FRANCESCA; JAFFA,AYAD A. |
| In addition to the induction of cell proliferation and migration, bradykinin (BK) can increase c-fos mRNA expression, activate ERK 1/2 and generate reactive oxygen species (ROS) in vascular smooth muscle cells (VSMC). It is not known, however, whether BK can induce cellular proliferation and extracellular matrix production via redox-sensitive signaling pathways. We investigated the role(s) of ROS in proliferation, migration and collagen synthesis induced by BK in VSMC derived from Sprague Dawley rat aorta. BK (10 nM) increased VSMC proliferation by 30 % (n=5); this proliferation was inhibited by the antioxidants N-acetylcysteine (20 mM) and a-lipoic acid (LA, 250 mM). In addition, BK induced an increase in cell migration and in collagen levels that were... |
| Tipo: Journal article |
Palavras-chave: Bradykinin; Antioxidants migration signal transduction reactive oxygen species. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300007 |
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