Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Anais da ABC (AABC) (1) Biol. Res. (1) Autor VINET,RAÚL (2) BENITES,JULIO (1) CORTÉS,MAGDALENA (1) DELPIANO,MARCO A (1) GOMEZ,HAROLD (1) JAIMES,LUISAURIS (1) LAURIDO,CLAUDIO (1) LUXORO,MARIO (1) MARTINEZ,JOSÉ L. (1) VARGAS-RUEDA,SILVIA (1) Mais... Palavra-chave Antioquine (1) Calcium antagonism (1) Capillary (1) Endothelial cells (1) Intracellular Ca2+ (1) Nicotinic receptor (1) Rat thoracic aorta (1) Tetrandrine (1) Verapamil (1) Voltage-activated Ca2+ channels (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2018 (1) 2009 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effects of two bisbenzylisoquinoline alkaloids, Antioquine and Tetrandrine, compared to Verapamil in Rat Thoracic Aorta Anais da ABC (AABC) MARTINEZ,JOSÉ L.; BENITES,JULIO; GOMEZ,HAROLD; VARGAS-RUEDA,SILVIA; VINET,RAÚL; JAIMES,LUISAURIS; LAURIDO,CLAUDIO. ABSTRACT The objective of this study was to compare two alkaloids (antioquine and tetrandrine) with verapamil; knowing that the smooth muscle respond to KCl and relationships with calcium. The effects of antioquine and tetrandrine, was studied in adults Wistar rat with modified methods used in the determination of aorta contractility and compared with verapamil effect in the same assays. The analysis of the effect of a drug or extract on aortic reactivity included maximal relaxation or maximal contraction (Cmax) (Phase 1). In our results, verapamil induced a blockade of 98.7 ± 0.7% (n = 6) in presence of endothelium and 97.9 ± 4.3% in ausence of endothelium, both in phase 1 and in phase 2 of 47.4 ± 4.1% (n = 6) in aortas in the presence of endothelium and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antioquine; Tetrandrine; Verapamil; Calcium antagonism; Rat thoracic aorta. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000401459 Nicotine-evoked cytosolic Ca2+ increase and cell depolarization in capillary endothelial cells of the bovine adrenal medulla Biol. Res. VINET,RAÚL; CORTÉS,MAGDALENA; LUXORO,MARIO; DELPIANO,MARCO A. Endothelial cells are directly involved in many functions of the cardiovascular system by regulating blood flow and blood pressure through Ca2+ dependent exocitosis of vasoactive compounds. Using the Ca2+ indicator Fluo-3 and the patch-clamp technique, we show that bovine adrenal medulla capillary endothelial cells (B AMCECs) respond to acetylcholine (ACh) with a cytosolic Ca2+ increase and depolarization of the membrane potential (20.3±0.9 mV; n=23). The increase in cytosolic Ca2+ induced by 10µM ACh was mimicked by the same concentration of nicotine but not by muscarine and was blocked by 100 µM of hexamethonium. On the other hand, the increase in cytosolic Ca2+ could be depressed by nifedipine (0.01 -100 µM) or withdrawal of extracellular Ca2+. Taken... Tipo: Journal article Palavras-chave: Capillary; Endothelial cells; Intracellular Ca2+; Nicotinic receptor; Voltage-activated Ca2+ channels. Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100012 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco