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| Votto,Ana P. S; Domingues,Beatriz S; de Souza,Michele M; da Silva Júnior,Flavio M. R; Caldas,Sergiane S; Filgueira,Daza M. V. B; Clementin,Rosilene M; Primel,Ednei G; Vallochi,Adriana L; Furlong,Eliana B; Trindade,Gilma S. |
| Onion (Allium cepa) is being studied as a potential anticancer agent, but little is known regarding its effect in multidrug resistance (MDR) cells. In this work, the cytotoxicity of crude onion extract (OE) and fractioned extract (aqueous, methanolic and ethyl acetate), as well as some onion compounds (quercetin and propyl disulfide) were evaluated in Lucena MDR human erythroleukemic and its K562 parental cell line. The capacity of OE to induce apoptosis and/or necrosis in these cells, the possible participation of oxidative stress and DNA damage were also assessed. Similar sensitivities were obtained for both tumoral cells, however only OE caused significant effects in the cells. In K562 cells, a significant increase of apoptosis was verified while the... |
| Tipo: Journal article |
Palavras-chave: Antioxidant; Apoptosis and/or necrosis; DNA damage; MDR phenotype; Onion (Allium cepa); Tumoral cell. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400007 |
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