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	Provedor de dados Genet. Mol. Biol. (1) Autor Cazarolli,Juciana (1) Chies,José Artur Bogo (1) Salzano,Francisco Mauro (1) Schiengold,Marion (1) Veit,Tiago Degani (1) Palavra-chave Amerindians (1) Balancing selection (1) HLA-G 14 bp INDEL (1) Pathogen resistance (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última New evidence for balancing selection at the HLA-G locus in South Amerindians Genet. Mol. Biol. Veit,Tiago Degani; Cazarolli,Juciana; Salzano,Francisco Mauro; Schiengold,Marion; Chies,José Artur Bogo. HLA-G is a non-classical HLA (Human Leukocyte Antigen) molecule characterized by limited tissue distribution under normal physiological conditions and low variability at both DNA and protein levels. Several studies suggest that HLA-G could play a role, as an immunoregulatory molecule, in situations as diverse as transplantation, cancer, viral infections and inflammatory diseases. A total of 237 individuals from 21 South American tribes speaking nine different linguistic families were studied in relation to the 14 bp insertion/deletion polymorphism at the HLA-G gene. A consistent (seven in nine) excess of heterozygosity in samples classified by language was obtained. Our data supply evidences for balancing selection acting at the HLA-G 14 bp INDEL region.... Tipo: Info:eu-repo/semantics/article Palavras-chave: HLA-G 14 bp INDEL; Balancing selection; Amerindians; Pathogen resistance. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000600005 Registros recuperados: 1 Primeira ... 1 ... Última

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