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| Wiens,Astrid; Lenzi,Luana; Venson,Rafael; Pedroso,Maria Lúcia Alves; Correr,Cassyano Januário; Pontarolo,Roberto. |
| The aim of this study was to conduct a cost-utility study of adefovir, entecavir, interferon alpha, pegylated interferon alpha, lamivudine and tenofovir for chronic hepatitis B in the context of Brazilian Public Health Care System. A systematic review was carried out for efficacy and safety. Another review was performed to collect utility data and transition probabilities between health states. A Markov model was developed in a time horizon of 40 years with annual cycles for three groups of: HBeAg positive, HBeAg negative, and all patients. These strategies were compared to a fourth group that received no treatment. Discount rates of 5% were applied and sensitivity analyses were performed. Tenofovir offered the best cost-utility ratio for the three... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic hepatitis B; Economic evaluation; Treatments. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400006 |
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| Correr,Cassyano Januário; Pontarolo,Roberto; Souza,Rodrigo Augusto de Paula e; Venson,Rafael; Melchiors,Ana Carolina; Wiens,Astrid. |
| The aim is to evaluate the humanistic outcomes in type 2 diabetic patients by the adoption of pharmacotherapy follow-up in community pharmacies. Controlled, non-randomized, 12-months trial; n=161 patients distributed into control and intervention groups; 6 community pharmacies involved, all in the Curitiba city region, in the state of Paraná were used. The health-related quality of life (HRQoL) and the satisfaction index were determined using both the DQOL assessment tool, which measures HRQoL, and the satisfaction evaluation tool (QSSF). Interventions on 119 negative therapeutic outcomes were done (2.3/patient [SD=1.6]); the most commonly found problems were related to ineffectiveness of pharmacotherapy (68.1%). The Intervention-Group showed a significant... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes mellitus/type 2/pharmaceutical care; Pharmaceutical care; Community pharmacy; Pharmacists/community action. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400027 |
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| Sanches,Andréia Cristina Conegero; Correr,Cassyano Januário; Venson,Rafael; Gonçalves,Patrícia Rodrigues; Garcia,Mariana Martins; Piantavini,Mário Sérgio; Pontarolo,Roberto. |
| All patients with Diabetes Mellitus (DM) receive insulin therapy. In this study, we evaluated the efficacy, safety and tolerability of human insulin and insulin analogues. We performed a systematic review of the literature and a meta-analysis according to the Cochrane Collaboration methodology. In the absence of clinical studies comparing insulins, we performed a mixed treatment comparison to establish the differences between the active treatments. We included studies published from 1995 to 2010. HbA1c results, episodes of hypoglycemia and nocturnal hypoglycemia data were extracted and analyzed. Thirty-five randomized clinical trials were selected after examining the abstract and a full text review. These studies included 4,206 patients who received... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insulins/meta-analysis; Diabetes mellitus/type 1; Insulin/treatment efficacy; Insulin/safety use. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300011 |
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| Venson,Rafael; Wiens,Astrid; Correr,Cassyano Januário; Pontarolo,Roberto. |
| The objective is to provide an update on the clinical efficacy, safety and tolerability of the use of abatacept for treating rheumatoid arthritis. A systematic review (up to June 2011) followed by meta-analyses was performed. Randomized controlled clinical trials comparing abatacept at a dose of 10 mg/kg with a placebo, both with concomitant methotrexate, were used. Only high- or moderate-quality studies were included. The efficacy was evaluated based on changes in the ACR, DAS and HAQ; safety was assessed based on serious adverse events, serious infections, malignancies and deaths; tolerability was evaluated based on the withdrawals due to adverse events, serious adverse events and lack of efficacy. All these parameters were evaluated within one year of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Abatacept/efficacy; Rheumatoid arthritis/treatment; Meta-analyses. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400022 |
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