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| Valença,A.M.; Nardi,A.E.; Nascimento,I.; Zin,W.A.; Versiani,M.. |
| The aim of the present study was to verify the sensitivity to the carbon dioxide (CO2) challenge test of panic disorder (PD) patients with respiratory and nonrespiratory subtypes of the disorder. Our hypothesis is that the respiratory subtype is more sensitive to 35% CO2. Twenty-seven PD subjects with or without agoraphobia were classified into respiratory and nonrespiratory subtypes on the basis of the presence of respiratory symptoms during their panic attacks. The tests were carried out in a double-blind manner using two mixtures: 1) 35% CO2 and 65% O2, and 2) 100% atmospheric compressed air, 20 min apart. The tests were repeated after 2 weeks during which the participants in the study did not receive any psychotropic drugs. At least 15 of 16 (93.7%)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: CO2; Anxiety; Breathing; Respiration. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700004 |
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| Nardi,A.E.; Valença,A.M.; Freire,R.C.; Mochcovitch,M.D.; Amrein,R.; Sardinha,A.; Levitan,M.N.; Nascimento,I.; de-Melo-Neto,V.L.; King,A.L.; de O. e Silva,A.C.; Veras,A.B.; Dias,G.P.; Soares-Filho,G.L.; da Costa,R.T.; Mezzasalma,M.A.; de Carvalho,M.R.; de Cerqueira,A.C.; Hallak,J.E.; Crippa,J.A.; Versiani,M.. |
| The objective of the present randomized, open-label, naturalistic 8-week study was to compare the efficacy and safety of treatment with clonazepam (N = 63) and paroxetine (N = 57) in patients with panic disorder with or without agoraphobia. Efficacy assessment included number of panic attacks and clinician ratings of the global severity of panic disorders with the clinical global impression (CGI) improvement (CGI-I) and CGI severity (CGI-S) scales. Most patients were females (69.8 and 68.4% in the clonazepam and paroxetine groups, respectively) and age (mean ± SD) was 35.9 ± 9.6 years for the clonazepam group and 33.7 ± 8.8 years for the paroxetine group. Treatment with clonazepam versus paroxetine resulted in fewer weekly panic attacks at week 4 (0.1 vs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Paroxetine; Clonazepam; Panic disorder; Efficacy; Safety. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400015 |
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