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Erratum in «High rate of virologic supression with darunavir/ritonavir plus optimazed background therapy among highly antiretroviral-experienced HIV-infected patients: results of a prospective cohort study in São Paulo, Brazil» BJID
Vidal,José Ernesto; Song,Alice Tung Wan; Matos,Maria Laura; Bartmann,Daniel; Anjos,Guilherme dos; Miranda,Érique José Peixoto de; Freitas,Ângela Carvalho; Dalben,Mirian de Freitas; Santana,Claudinei; Segurado,Aluísio Cotrim; Barreto,Cláudia Cortese; Hernández,Adrián Vladimir.
Tipo: Info:eu-repo/semantics/other
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300017
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Molecular diagnosis of cerebral toxoplasmosis: comparing markers that determine Toxoplasma gondii by PCR in peripheral blood from HIV-infected patients BJID
Mesquita,Rafael Tonini; Vidal,José Ernesto; Pereira-Chioccola,Vera Lucia.
As cerebral toxoplasmosis is the most common cerebral focal lesion in AIDS patients, this study evaluated three PCR markers for diagnosis, since some limitations remain present, such as low parasite levels in some clinical samples. The molecular markers were B22-B23 and Tg1-Tg2 (based on the B1 gene) and Tox4-Tox5 (non-coding fragment, repeated 200-300-fold). DNA samples from 102 AIDS patients with previously known diagnosis were analyzed. The cerebral toxoplasmosis group was constituted of DNA extracted from the blood of 66 AIDS patients, which was collected before or until the third day of the therapy for toxoplasmosis. DNA from the blood of 36 AIDS patients with other neurologic opportunistic infections was used as control group. Sensitivities of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: AIDS; Cerebral toxoplasmosis; Molecular diagnosis; PCR markers.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400006
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High rate of virologic suppression with darunavir/ritonavir plus optimized background therapy among highly antiretroviral-experienced HIV-infected patients: results of a prospective cohort study in São Paulo, Brazil BJID
Vidal,José Ernesto; Song,Alice Tung Wan; Matos,Maria Laura; Bartmann,Daniel; Anjos,Guilherme dos; Miranda,Érique José Peixoto de; Freitas,Ângela Carvalho; Dalben,Mirian de Freitas; Santana,Claudinei; Segurado,Aluísio Cotrim; Barreto,Cláudia Cortese; Hernández,Adrián Vladimir.
OBJECTIVES: To assess the virologic and immunological response of darunavir/ritonavir plus optimized background therapy in highly antiretroviral-experienced HIV-infected patients in Brazil. METHODS: Prospective cohort study carried out in a tertiary center in Sao Paulo, Brazil. Three-class antiretroviral-experienced patients with confirmed virologic failure began darunavir/ritonavir plus optimized background therapy (nucleoside/tide reverse transcriptase inhibitors ± raltegravir ± enfuvirtide ± maraviroc) after performing a genotypic resistance assay. Clinical evaluation and laboratory tests were collected at baseline and at weeks 12, 24, and 48. Multivariate analysis was performed to identify predictors of virologic response at 48 weeks. RESULTS:...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Highly active antiretroviral therapy; Darunavir; Acquired immunodeficiency syndrome; Developing countries.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100007
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JC virus-associated central nervous system diseases in HIV-infected patients in Brazil: clinical presentations, associated factors with mortality and outcome BJID
Piza,Felipe; Fink,Maria Cristina; Nogueira,Gilberto S.; Pannuti,Claudio S.; Oliveira,Augusto C. Penalva de; Vidal,José Ernesto.
INTRODUCTION: Several presentations of neurologic complications caused by JC virus (JCV) in human immunodeficiency virus (HIV)-infected patients have been described and need to be distinguished from the "classic" form of progressive multifocal leukoencephalopathy (PMl). The objectives of this study were: 1) to describe the spectrum and frequency of presentations of JCV-associated central nervous system (CNS) diseases; 2) identify factors associated with in-hospital mortality of patients with JCV-associated CNS disease; and 3) to estimate the overall mortality of this population. MATERIAL AND METHODS: This was a retrospective study of HIV-infected patients admitted consecutively for JCVassociated CNS diseases in a referral teaching center in São Paulo,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: JC virus leukoencephalopathy; Progressive multifocal Diagnosis Acquired immunodeficiency syndrome Brazil.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200008
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