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| Falagan-Lotsch,Priscila; Rodrigues,Marina S.; Esteves,Viviane; Vieira,Roberto; Amendola,Luis C.; Pagnoncelli,Dante; Paixão,Júlio C.; Gallo,Claudia V. De Moura. |
| The X-ray repair cross-complementing Group1 (XRCC1) gene has been defined as essential in the base excision repair (BER) and single-strand break repair processes. This gene is highly polymorphic, and the most extensively studied genetic changes are in exon 6 (Arg194Trp) and in exon 10 (Arg399Gln). These changes, in conserved protein sites, may alter the base excision repair capacity, increasing the susceptibility to adverse health conditions, including cancer. In the present study, we estimated the frequencies of the XRCC1 gene polymorphisms Arg194Trp and Arg399Gln in healthy individuals and also in women at risk of breast cancer due to family history from Rio de Janeiro. The common genotypes in both positions (194 and 399) were the most frequent in this... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: XRCC1 gene polymorphisms; Breast cancer susceptibility; Brazilian population. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200008 |
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