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| Vijaya Dubey; Nusrat Masood; Suaib Luqman; Arvind S. Negi. |
| Cancer, one of the leading causes of death worldwide, is an abnormal cell proliferation that fails to respond to the normal signals. In an effort to eradicate the growing menace of cancer, a clear understanding of fundamental biology and molecular mechanism of carcinogenesis is essential for targeted therapies. Among the devised strategies in use for cancer treatment, the one that is of immense interest is the development of plant based novel anticancer agents. Due to their tremendous availability, biological activity and efficacy, the phytochemicals deemed a gibbous future in chemoprevention. In the present study, several phenolics based structurally related compounds of steroidal and non-steroidal skeleton were synthesized and tested for their... |
| Tipo: Poster |
Palavras-chave: Cancer; Chemistry; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6644/version/1 |
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| Nusrat Masood; Vijaya Dubey; Suaib Luqman. |
| Biomarkers of cancer have made a strong traipse in predicting the disease pattern and contributed significantly to the understanding of tumour state, progression, characteristics and response to therapies. Polyamines such as putrescine, spermine and spermidine are cationic biomolecules essential for the cell cycle function and serve as excellent biomarkers of tumour progression. The polyamine biosynthesis is tightly regulated by ornithine decarboxylase, a highly inducible enzyme specific to pH, temperature, time and substrate concentration. The expression of this enzyme is very high during cell transformation and tumour progression leading to elevated level of polyamines. To measure the activity of ornithine decarboxylase an improved, easy, simple,... |
| Tipo: Poster |
Palavras-chave: Cancer; Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6643/version/1 |
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