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Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses Genet. Mol. Biol.
Silva,Aline Correa da; Brass,Karin Erica; Loreto,Elgion da Silva; Vinocur,Myriam Elizabeth; Pozzobon,Ricardo; Azevedo,Marcos da Silva.
The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO, although no association was found between polymorphism and horses with either RAO or IAD.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Horse; Respiratory disease; SSCP; Alpha-1-antitrypsin; Serpin.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300015
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Genetic variability in the brazilian criollo horse breed Ciência Rural
Vinocur,Myriam Elizabeth; Brass,Karin Erica; Rubin,Mara Iolanda Batistella; Silva,Carlos Antonio Mondino.
Allelic frequencies of 7 blood groups and 8 protein systems were determined in 6 herds of Criollo horse breed raised in Rio Grande do Sul, Brazil. Analysis of these frequencies showed a significant isolation component (Fst = 0.0866; p<0.01) and construction of dendogram using Nei´s D confirmed this difference among the 6 herds. The highest values measuring genetic variability on 15 blood types were average heterozygosity: 0.4631; total number of alleles: 87 and probability of exclusion: 98%. When all herds were considered together, the inbreeding level (Fis) was zero. These results indicate that the Criollo horses have a large genetic variability.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Blood groups; Protein systems; Geneticvariability horse.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782003000100022
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