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	Provedor de dados Nature Precedings (2) Autor Vivek Gupta (2) Asif Husain Naqvi (1) Asif Naqvi (1) Hardik H. Sheth (1) Jayendra Tanwar (1) Kaushlesh Mishra (1) Suchindran H S (1) Vijay Kumar (1) Mais... Palavra-chave Bioinformatics (2) Pharmacology (2) Cancer (1) Tipo do documento Manuscript (1) Presentation (1) Ano 2011 (2) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Study Of Phenothiazine On p53 Core Domain Mutant Y220C: Finding The Anti-tumor Activity Of Phenothiazine Nature Precedings Asif Husain Naqvi; Hardik H. Sheth; Vijay Kumar; Suchindran H S; Vivek Gupta. The tumor suppressor protein p53 is a transcription factor that plays a key role in the prevention of cancer development. The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small molecules. We have attempted with the help of virtual screening and molecular docking approach using Lamarckian Genetic Algorithm to elucidate the extent of specificity of p53 cancer mutation Y220C towards different class of Phenothiazines (an anti-cancer agent). 

The 393 residue p53 tumor suppressor protein exists in a dynamic equilibrium to form homotetramers. Each chain comprises several functional domains. The N terminal part of the protein consists of the... Tipo: Presentation Palavras-chave: Cancer; Pharmacology; Bioinformatics. Ano: 2011 URL: http://precedings.nature.com/documents/6135/version/1 Molecular Modeling study of Protein Kinase PKnB from Mycobacterium Tuberculosis with derivatives of 1, 3, 4- Thiadiazoles Nature Precedings Vivek Gupta; Asif Naqvi; Jayendra Tanwar; Kaushlesh Mishra. Tuberculosis causes more than two million deaths per year. Faced with this global threat it is crucial to better understand the physiology of the causative organism, Mycobacterium Tuberculosis, in order to develop efficient therapeutic strategies. PKnB from Mycobacterium tuberculosis is a crucial receptor-like protein kinase involved in signal transduction. M. tuberculosis PKnB is a trans-membrane Ser/Thr protein kinase (STPK) highly conserved in Gram-positive bacteria and apparently essential for Mycobacterial viability. We have attempted with the help of virtual screening and docking approaches to expound the extent of specificity of protein kinase B towards different classes of Thiadiazoles (an anti-tubercular agent). The selected Thiadiazoles were... Tipo: Manuscript Palavras-chave: Pharmacology; Bioinformatics. Ano: 2011 URL: http://precedings.nature.com/documents/6136/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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